Hypotheses on the etiology and pathogenesis of type 1 diabetes

[jccgf]

I've been watching the research in regard to the relationship between celiac disease and diabetes, and thought some might find this interesting~


This paper presents a series of 10 hypotheses on the etiology of type 1 diabetes. We begin with the hypothesis that wheat gluten is one of the elusive environmental triggers in type 1 diabetes.
Putting the pieces of the puzzle together - a series of hypotheses on the etiology and pathogenesis of type 1 diabetes (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17045415&itool=pubmed_DocSum). PMID: 17045415 Oct 2006


More below on zonulin, and its possible role in type 1 diabetes, MS, celiac disease, and other autoimmune disease. This research is early, but it will be interesting to see where it all leads in the next ten years.

Zonulin (http://jccglutenfree.googlepages.com/zonulin)

On celiac disease and its relationship to:
Type 1 Diabetes and Autoimmune Thyroid Disease (http://jccglutenfree.googlepages.com/type1diabetesandautoimmunethyroiddisease)


Cara

[jccgf]

Systemic autoimmune disorders in celiac disease (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17053448&query_hl=8&itool=pubmed_docsum). PMID: 17053448 Nov 2006


Fasano A.
Center for Celiac Research and Mucosal Biology Research Center and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
PURPOSE OF REVIEW: Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established. RECENT FINDINGS: Two main theories have been postulated to explain this comorbidity: (1) linkage disequilibrium between the genes responsible for celiac disease and those responsible for the coexpressed autoimmune diseases or (2) untreated celiac disease leading to the onset of other autoimmune diseases. This article reviews the current literature supporting either theory and places the current knowledge in the field within the context of the most recent data on the pathogenesis of celiac disease. SUMMARY: The current literature did not clearly establish which of the two theories explain the comorbidity between celiac disease and other autoimmune disorders. There is, however, growing evidence that the loss of the intestinal barrier function typical of celiac disease could be responsible of the onset of other autoimmune disease. This concept implies that the autoimmune response can be theoretically stopped and perhaps reversed if the interplay between autoimmune predisposing genes and trigger(s) is prevented or eliminated by a prompt diagnosis and treatment.
PMID: 17053448