Citocline Heals brain Damage~ eat your orange peels!

[CTenaLouise]

Eat Your Orange Peel!

Everyone knows that citrus fruits -- oranges,
lemons, and grapefruits -- are a healthy food.
Packed with vitamin C and bioflavonoids,
citrus fruits are to many of us the fresh,
sunny taste of good health. But while many
people may enjoy the flesh of oranges as a
regular part of their healthy diet, few of us
eat the intensely-flavored peels of these fruits.
That might turn out to be a major error in
judgement. New research suggests that we
may have been throwing away the best part
of the fruit!

For some years now, scientists have been
quietly investigating limonene, the major
component of the essential oil in orange
peels, as a potential anti-cancer nutrient.1 In
animal models, limonene powerfully
prevents tumors of the breast, liver,
stomach, skin, and lung, whether given
before exposure to a cancer-causing agent, or
even after the first cancerous cells have
formed.

Partly, limonene seems to work by
enhancing the body’s phase II
detoxification enzymes, which make
cancer-causing chemicals more readily
excreted by the body in the urine or bile; as
well, limonene appears to induce
programmed cell suicide (apoptosis) and
to block a step (isoprenylation) required for
the proteins made by cancer genes
(oncogenes) to wreak their havoc. Most
excitingly, limonene appears to somehow
induce “redifferentiation,” forcing rogue
cancer cells to settle down and return to their
normal functions in the body.

Studies are under way to
see if limonene can be
used by people with
cancer.

Citicoline Heals Brain Damage:

Cytidine diphosphate choline, or Citicoline
for short, is an orthomolecule with a vital job
to play in manufacturing the brain’s
phospholipids (like phosphatidylserine
[PS] and phosphatidylcholine [PC]). In a
recent article (see “PS: Remember Your
Citicoline!” in The Holistic Lifestyle 1[5]), we
reviewed some of the evidence that
Citicoline provides powerful nutritional
support in many serious disorders of the
brain, as well as in the loss of memory
associated with “normal” aging.

Much of the research on Citicoline has
focussed on its ability to help restore healthy
brain function after a stroke. Animal studies4
show that Citicoline reduces the size of
the brain injury which results when an
experimental stroke cuts off the brain’s
oxygen supply. The question is, how?
Experiments on animals5.6 have suggested
that Citicoline has both preventative and
regenerative effects on the brain injuries which
follow a stroke. On the one hand, strokes
usually force brain cells to release some of
the fatty acids out of their membranes, a
process which can increase the damage
inflicted on neurons by free radicals. Animal
studies have shown that Citicoline reduces
this release of free fatty acids, preventing
excess free radical damage during a
stroke.
PDF
http://www.aor.ca/int/magazines/pdf/Holistic_Lifestyle_2001_May_Issue_6_Eat_Your_Orang e_Peel.pdf

[reverett123]

I would point out that our own Ron Hutton has taken citicholine (aka CDPcholine) for years and has held up quite well.

[Ronhutton]

Thanks Rick, Yes I have taken CDP choline or citicoline as it is sometimes called, for about 6 years now, in combination with curcumin. I take one 250mg of citicoline per day, with one or 2 curcumin capsules 500mg each.I buy both from iHerb.
I do credit it with slowing down my progression. I have had PD for 17 years now, and I am doing well, but I have been accused of boasting about it. However, I am only trying to pass the message on to help others, and cheer up newly diagnosed with the message that life does not need to stop when you suffer from PD. Last year, I coped with a total of 40 hours in a plane going to Tahiti for 2 weeks holiday.
On the boat holiday, I managed one day on one 50mg Sinemet tablet, but other days were poor.and I needed a max of 300mg. Still not bad for 17 years since diagnosis, although I am continuing to deteriorate, but slowly.
Over last year, I fell a couple of times and permanently damaged my shoulder.
Best wishes to all
Ron

[reverett123]

Just kidding, but I do think it good to point out some things that Ron might not want to lest he seem a braggart. :) But these are very important for the archive because we have a limited number of longtime warriors and scientifically trained ones at that. In short, Ron is one of our more valuable "rats", and, while I count him a friend, it is his value as a longterm experiment I am speaking of here.

First, he has held up rather well for a long time. Either he is one of the lucky minority (not likely) or something he has been doing has made a difference. Curcumin and citicholine are prime candidates.

Second, he has held up under some real tests. "Stress tested." His bout with the bad tooth was the most recent. Then there was the swan dive through the plate glass of his greenhouse. Struggles with medication changes. His load of PD challenges has been as great as most.

Yet, he keeps on ticking. And in doing so he shows that there is hope and that these things we come up with to test do have potential. He is a valuable white rat. :D

Thanks Rick, Yes I have taken CDP choline or citicoline as it is sometimes called, for about 6 years now, in combination with curcumin. I take one 250mg of citicoline per day, with one or 2 curcumin capsules 500mg each.I buy both from iHerb.
I do credit it with slowing down my progression. I have had PD for 17 years now, and I am doing well, but I have been accused of boasting about it. However, I am only trying to pass the message on to help others, and cheer up newly diagnosed with the message that life does not need to stop when you suffer from PD. Last year, I coped with a total of 40 hours in a plane going to Tahiti for 2 weeks holiday.
On the boat holiday, I managed one day on one 50mg Sinemet tablet, but other days were poor.and I needed a max of 300mg. Still not bad for 17 years since diagnosis, although I am continuing to deteriorate, but slowly.
Over last year, I fell a couple of times and permanently damaged my shoulder.
Best wishes to all
Ron

[lurkingforacure]

That is so great, and you, Rick, sound as if you are holding up pretty well yourself, so something you all are doing is working. We can see what all Rick takes from his posts (see the bottom list), but would Ron please be willing to share what all he takes? Everyone is different, yes, and nothing is to be construed as medical advice, yes, etc., etc., but it would really help so everyone can compare.

I find it interesting that Ron takes dextromorphan, yet Rick does not (did I get this right?) But both seem to be holding up very well. Thoughts about this?

[reverett123]

My signature line is a little misleading. It is not that I am always taking all those, though at times I am. But when I am actively testing something new I often put some or all of the others aside temporarily. For example, right now I am testing mucuna and also taking Acetyl-L-carnitine and alpha lipoic acid and a multi and ginseng. But all the ones I list I have evaluated and tested and consider them to be a part of my regimen. Between tests I try to take them all but one grows sick of pills. I find that I do best if I have my list to keep track of what is proven to me and take as many as I can without stressing about it.

As to the dex, it is on my someday list but I am what they call a "slow metabolizer" for it (a little goes a long way) and I just don't want to add to my liver's burden.

[Ronhutton]

Quote, "would Ron please be willing to share what all he takes?"
Yes of course, I take the following
Curcumin one to two 500mg
citicoline 250mg
acetyl L carnitine 750mg
alpha lipoic acid 300mg
Since infections can have such a devastating effect, I also take a garlic capsule 1000mg and a spoon of Manuka honey.

Rick, thanks for your kind words.
Ron

[lurkingforacure]

Many, many thanks for sharing, so glad you are doing so well at 16 years!.

[CTenaLouise]

Many, many thanks for sharing, so glad you are doing so well at 16 years!.

I have been dxd officially for 15 yrs. but in the early 1990's it was rare to get the PD diagnosis - neurologist's etc, only thought PD happened to seniority
citizens?
I was 30 -way back then... :rolleyes:

[lurkingforacure]

I didn't know that, that is also a long time (our neuro told us 8-12 years, wheelchair around the 5th year, and then a slow decline, his exact words were "it's usually the pnuemonia that'll get ya", so comforting, those doctors), so it's great to hear that so many are doing so well so far out. And the thing I have noticed about all of that group, including yourself, pretty much without exception: all of you are doing alternative things, none have stuck strictly with the traditional Rx drugs. Those that have....sadly, I do not see that they are still around. Unless I am missing something? That speaks volumes to me.

[rosebud]

Speaking for the traditionalists, some of us have hung in quite well on a mainstay of western style pharmaceuticals. But I will add a caveat to that: In my case,I have called the shots on how and when, and even how much. Makes my Neurologist crazy. I have a basic MO that I use as a guideline, but I adjust constantly. You could say I am an intuitive type. I am also very aware of what I eat and how that affects me. I am going into my 12th year. No wheelchair, no walker, as a matter of fact I just bought a pair of 4"heels! Tell your Dr. to stick that in his pipe and smoke it! There is soo much to say on this topic that you would be reading for days. So young man, pack your wagon and head west. The new frontier is being discovered and we are its pioneers.
It's a rough road but hey, somebody's gotta go there. The alternative is just not acceptable! I do dabble in extra curricular supplementation, but as someone before me said, taking pills constantly gets tedious. No Kidding!

[reverett123]

You need a new neuro :)

I didn't know that, that is also a long time (our neuro told us 8-12 years, wheelchair around the 5th year, and then a slow decline, his exact words were "it's usually the pnuemonia that'll get ya", so comforting, those doctors), so it's great to hear that so many are doing so well so far out. And the thing I have noticed about all of that group, including yourself, pretty much without exception: all of you are doing alternative things, none have stuck strictly with the traditional Rx drugs. Those that have....sadly, I do not see that they are still around. Unless I am missing something? That speaks volumes to me.

[CTenaLouise]

I didn't know that, that is also a long time (our neuro told us 8-12 years, wheelchair around the 5th year, and then a slow decline, his exact words were "it's usually the pnuemonia that'll get ya", so comforting, those doctors), so it's great to hear that so many are doing so well so far out. And the thing I have noticed about all of that group, including yourself, pretty much without exception: all of you are doing alternative things, none have stuck strictly with the traditional Rx drugs. Those that have....sadly, I do not see that they are still around. Unless I am missing something? That speaks volumes to me.

that is the bad news doctor?
whew!
my doctor/ neurosurgeon - after telling me the news of the PD scourge,
I cried - and he comforted me, when I asked if there was a cure,
he sad no not yet, but it was seriously being studied -& I could have a cure in 5-to 10 years, I spoke to so many awesome brilliant minds doctors -neurosurgeons, neuro scientist -that wass in my advocacy daze... :cool:
& now - I try to help many of you, young onset patients - like I was...

so realize the doctor that doesnt know squat -we each have our own type
of PD -there is no schedule for this illness, I wear a two inch heel, because
for some reason - it is easier for walking -also - I can run still and on great
energy days, I can dance... I am blessed - namely because I know that
the info that doc gave was crapola...
have patience with yourself - you will do just fine...
bless your heart -

[CTenaLouise]

continued info

History:
Orange Peel is the ripened rind (which sometimes becomes more potent with age) of the Orange and is particularly rich in vitamin C. Contrary to popular belief, the Orange is not native to China. Although its descendence is not exactly known, its origins appear to be in northern and northeastern India, and it was well-known in China and Indo-China as a medicine in the first century A.D. Orange Peel is still used in China today (Citrus sinensis) in Traditional Chinese Medicine (TCM) as an ingredient in different drugs. There is a great deal of current research being conducted lately with respect to Orange (and Lemon) Peel and its powerful constituent, d-limonene, a cyclic monoterpene that causes G1 cell cycle arrest, but thus far, no conclusions have been drawn, and further research is needed. (You may wish to check out the Memorial Sloan-Kettering site for further information about cancer research and d-limonene here). The fruit known as the Seville Orange was first brought to Europe by the Moors in the ninth century and grown in the Arabic realms of Spain and Sicily; sweeter Oranges came to the continent later with Portuguese traders. Columbus introduced the Orange to the West Indies, and the fruit was well established in Florida before 1565. Oranges were growing in California by 1800. The smallish trees grow in well-drained soil in sun with ample moisture in warm climates and do not transplant well. They are susceptible to many different insects and fungal diseases and are also quite sensitive to frost. Orange happens to be the most imported fruit in international commerce, both as a popular and most nutritious food on its own, but also as an ingredient in candies, marmalades, herbal medicine, cosmetics, soaps, perfumes, aromatherapy, etc. Orange Peel is one of the most important sources of vitamin C on earth (the Peel contains more than the pulp), and is also rich in citric acid and d-limonene. Other constituents include p-synephrine, pectin, volatile oils, hesperidin, protein, carbohydrates, fiber, calcium, potassium, phosphorus, iron and vitamin A.

Beneficial Uses:
Orange Peel's high vitamin C content (and A) makes it a wonderful supplement to build immunity and combat invasive infection, colds, flu and many other ailments. Vitamin C is an antioxidant that protects your body's cells from damage, helps form the connective tissue collagen, keeps your capillaries and blood vessels healthy, and aids in the absorption of iron and folate.

http://www.herbalextractsplus.com/orange-peel.cfm