View Full Version : Piroxicam
11-27-2006, 06:26 PM
Hi there !
I thought I would ask if anyone is using this med. I have Aterial TOS and this is a med they put me on in case I get a bad flare up but I was told not to stay on it daily. Has anyone had any experience ?
A cloud of suspicion hangs over it even today.
It is hardly used anymore.
I suggest you discuss this with your doctor. Why this particular NSAID?
Sudoxicam was the first oxicam introduced to clinical research. It has documented disease-modifying effects in rheumatoid disease, as has benoxyprofen . But sudoxicam was withdrawn after its idiosyncratic hepatonecrotic potential was noted (rarely), and a number of related deaths ended all clinical testing.
Piroxicam, an analogue of sudoxicam, succeeded it. This approved NSAID was to lead to more deaths from gastrointestinal bleeding than had been documented with any other NSAID to date .
There were attempts at one time to take this off the market. Pfizer has
blocked those aggressively.
This is the drug info from Pfizer... http://www.pfizer.com/pfizer/download/uspi_feldene.pdf
In it are stats stating that continuous use for 8-12 weeks is necessary for therapeutic effect. So taking this intermittently exposes you to GI bleeding risk without therapeutic effect.
To date, naproxen is the only NSAID that has marginally passed the cardiovascular risk studies for NSAIDs. It too can cause GI issues, but they are less frequent than piroxicam.
GI bleeding risk has been found to vary from person to person.
This article reveals increased risk in those with autoimmune disorders:
If you take SSRIs for depression, risk is higher also.
Some studies show use of a proton pump inhibitor like Prilosec may reduce
risk of GI bleeding, so some doctors give them with NSAIDs.
This article is interesting, informative and suggests interventions and explains risk factors for GI bleeding:
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