another interesting use for off label therapy

[totade]

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Grant Abstract
Bee Venom as a Neuroprotective Agent in Parkinson’s Disease

Rapid Response Innovation Awards 2008

Objective/Rationale:

Based on a serendipitous obsrevation in one of our patients suffering from Parkinson’s disease, we wish to verify, in an animal model of the disease, whether bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons.

Project Description:

Mice will be injected with two substances which induce the slow loss of dopaminergic neurons in these animals. In parallel, these mice will be treated with bee venom or one of its components called apamine. We believe the latter to be largely responsible for the beneficial effects on the survival of dopaminergic neurons which we hope to demonstrate. The animals will be evaluated regarding their behaviour and post-sacrifice, analysed precisely regarding the function of the neuronal system underlying the motor features of Parkinson’s disease.

Relevance to Diagnosis/Treatment of Parkinson’s Disease:

Bee venom injections are used for desesentization treatments against allergies to bee venom. Usually, patients are injected once/monthly into the muscle. This treatment is safe, easy and cheap. If used in Parkinson’s disease patients, it could represent either an adjunct to existing symptomatic therapies, or even be used as a single therapy in the early disease course.

Anticipated Outcome:

We wish to know whether bee venom and/or its constituent, apamine, are able to slow or halt the disease process in Parkinson’s disease. We believe that these substances sustain the function of dopaminergic neurons, the neuronal cell type most severely affected in Parkinson’s disease. This study would pave the way for a first clinical trial, which would be fairly easy to organise since bee venom injections are considered to be safe and simple.

Researchers

Andreas Hartmann, MD
INSERM U 679, Pitié-Salpêtrière Hospital
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[reverett123]

Although NOT bee venom, I took desensitization shots on a continuous basis for WASP stings for fifteen years which overlapped my onset of symptoms about the half way point. Seemingly no effect, but wasp venom is entirely different from bee venom.


The Michael J. Fox Foundation for Parkinson's Research

* Home
* Donate Now
* News & Events
* Email Sign Up
* Text Size


* About the Foundation
* Research Programs
* Living With Parkinson's
* How You Can Help

Searchable Database of Funded Grants

The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution/organization name, or year.
Back to results list

Grant Abstract
Bee Venom as a Neuroprotective Agent in Parkinson’s Disease

Rapid Response Innovation Awards 2008

Objective/Rationale:

Based on a serendipitous obsrevation in one of our patients suffering from Parkinson’s disease, we wish to verify, in an animal model of the disease, whether bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons.

Project Description:

Mice will be injected with two substances which induce the slow loss of dopaminergic neurons in these animals. In parallel, these mice will be treated with bee venom or one of its components called apamine. We believe the latter to be largely responsible for the beneficial effects on the survival of dopaminergic neurons which we hope to demonstrate. The animals will be evaluated regarding their behaviour and post-sacrifice, analysed precisely regarding the function of the neuronal system underlying the motor features of Parkinson’s disease.

Relevance to Diagnosis/Treatment of Parkinson’s Disease:

Bee venom injections are used for desesentization treatments against allergies to bee venom. Usually, patients are injected once/monthly into the muscle. This treatment is safe, easy and cheap. If used in Parkinson’s disease patients, it could represent either an adjunct to existing symptomatic therapies, or even be used as a single therapy in the early disease course.

Anticipated Outcome:

We wish to know whether bee venom and/or its constituent, apamine, are able to slow or halt the disease process in Parkinson’s disease. We believe that these substances sustain the function of dopaminergic neurons, the neuronal cell type most severely affected in Parkinson’s disease. This study would pave the way for a first clinical trial, which would be fairly easy to organise since bee venom injections are considered to be safe and simple.

Researchers

Andreas Hartmann, MD
INSERM U 679, Pitié-Salpêtrière Hospital
Print This Page Email This Page

* Research Programs Main
* The MJFF Funding Philosophy
* Funding Opportunities
* Opportunities for Industry
* Searchable Database of Funded Grants
* MJFF Viewpoints
* For Grant Awardees
* Contact Scientific Staff
* Researcher Email Sign Up

Copyright © 2007 The Michael J. Fox Foundation for Parkinson's Research
Site Map Contact Us Privacy Policy Terms and Conditions

[edu-pd]

Wow! thanks for this!

Does this mean that bee keepers don't get Parkinson's ????

If only this really was an immediate cure!

It'd be great to hear any anecdotal info from PD beekepers and others.

Anyway, there's no harm investigating it . The first thing I always want is to access the product fast. So I did a few searches on how to get some …venom!! There seem to be at least two 'off label' 'do it yourself' options currently available.

1. The bee venom with honey . I am not sure if this is not all hype. I would check the supposed trials and doctors involved. The most trustworthy for me would be a NZ product. One is produced by Nelson Apiaries Ltd, called Nectarease, and distributed by them as well as a US co. at the wild bee site. Nelson Apiaries sells it at almost half the price for same product through their site theshop.co.nz. Good if you live in NZ or Australia. Other companies also selling venom in Manuka honey are API HEALTH and thehealthstore .co. in New Zealand .

2. Apitherapy- direct been sting applications. ( probably more similar to the French trial - but careful with this - bee sting anaphylaxis can kill). A site by Mihály Simics , Canada has a lot of info. Also check out the BTERFoundation for apitherapy organisations . I willl follow this one through for my mum, but she was once seriously allergic to some bee sting....

PP