Helicobacter Pylori

[Hanna]

I shall make it brief. Son who was diagnosed by Dr Fine last year has severe anemia. After a endoscopy last week they found "helicobacter pylori" but no gluten mal absorbtion. Basically, they think we are insane and he could eat gluten. France is behind the times.

Isn't there a direct relationship between CD and this?????

[jccgf]

We lost so much in the old forum... we had many threads on h. pylori. It is one of the pages I need to recreate in The Gluten File and haven't done yet.

WorriedMom's son also had h. pylori that needed to be erradicated. I wish I knew if my daughter did, and it is one of the many things I feel went untested.

H. pylori is a likely trigger for gluten sensitivity developing because it damages the gut lining... leaky gut from any cause results in problems.

These things often go together. Chicken and egg. Is the food sensitivity primary or secondary? h. pylori cause is, or does h.pylori get its foot in the gut due to already damaged gut and compromised immune system??

Given your family history, I can understand why you wouldn't want to jump back to gluten~ but, the h. pylori needs to go.

I'm going to go look for some of old pages, sometimes we can find cached copies and rescue our old data.

Well, I found this one on h. pylori:
http://64.233.167.104/search?q=cache:UQehO3Kiwu4J:brain.hastypastry.net/forums/showthread.php%3Ft%3D11201+braintalk+H.+pylori+Ted&hl=en&gl=us&ct=clnk&cd=2


H.Pylori is also associated with lymphocytic gastritis and colitis, but so is gluten sensitivity. The diagnostics can be confusing.
http://64.233.167.104/search?q=cache:IZ2OmyWsNV0J:brain.hastypastry.net/forums/showthread.php%3Fp%3D1072737+braintalk+H.+pylori+g luten+sensitivity&hl=en&gl=us&ct=clnk&cd=1

Thanks for the nudge to recover these. They'll soon be included in The Gluten File.

Nobody can say you can't have both h. phyori and celiac disease, but without a gold star diagnosis, nobody is going to call it celiac disease. It is good that the h. pylori was found! Finding other co-existing conditions is one of the pro's of having a biopsy done.

This study shows a significant association between H. pylori infection and iron-deficiency anaemia in patients with coeliac disease.
Link between Helicobacter pylori infection and iron-deficiency anaemia in patients with coeliac disease (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11761018). PMID: 11761018

Cara

[annelb]

Hi Hanna, sorry to hear that your son's doctors don't understand gluten sensitivity - frustrating. Did they even take biopsies of the small intestine. I have a friend who had an endoscopy and when gastritis and h. pylori were found, that was the end of the search - no biopsies other than of the stomach.


Here is a new article. Is it saying that 30 of the 80 people with CD had H.pylori? That is a large percentage.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Display&DB=pubmed

Am J Gastroenterol. 2006 Aug;101(8):1880-5. Epub 2006 Jun 16.

Helicobacter pylori Infection in patients with celiac disease.

Villanacci V, Bassotti G, Liserre B, Lanzini A, Lanzarotto F, Genta RM.

2nd Pathology Section, Spedali Civili, Brescia, Brescia, Italy.

BACKGROUND AND AIMS: Patients with Helicobacter pylori gastritis are more likely to have increased duodenal intraepithelial lymphocytes (IEL); this can be reversed by H. pylori eradication. We hypothesized that: (1) H. pylori-infected celiac disease (CD) patients could have different clinicopathological features from noninfected subjects; and (2) the histopathological responses to a gluten-free diet could be different in H. pylori-infected and noninfected patients. METHODS: Duodenal and gastric biopsies obtained from 80 adults with histologically and serologically confirmed CD before and after 12-18 months of a gluten-free diet were retrospectively evaluated. Gastritis was classified and scored according to the Updated Sydney System; duodenal biopsies were classified using both the Marsh-Oberhuber and a simplified classification proposed by our group. RESULTS: At baseline, 30 patients had H. pylori infection and 50 did not; at follow-up five new infections were detected. Fifteen patients (3 H. pylori-positive and 12 negative) had lymphocytic gastritis. At baseline, a greater proportion of H. pylori-negative patients had severe villous atrophy (p < 0.01), but milder forms were more prevalent in H. pylori-positive patients (p < 0.01). After a gluten-free diet, significant improvement occurred in all duodenal features (p < 0.001), irrespective of H. pylori status; gastric variables did not change, except for lymphocytic, which resolved in 2 infected and 10 noninfected patients. CONCLUSIONS: The clinical features of CD patients are unrelated to H. pylori gastritis, and a gluten-free diet is equally effective in infected as in uninfected patients. The higher prevalence of milder duodenal lesions in CD patients with H. pylori infection suggests that lymphocytosis induced by H. pylori gastric infection becomes less obvious as profound inflammatory and structural changes alter the mucosal architecture. This study also provides further support for a pathogenetic relationship between CD and lymphocytic gastritis.

PMID: 16780559 [PubMed - in process]

[stevel]

I shall make it brief. Son who was diagnosed by Dr Fine last year has severe anemia. After a endoscopy last week they found "helicobacter pylori" but no gluten mal absorbtion. Basically, they think we are insane and he could eat gluten. France is behind the times.

Isn't there a direct relationship between CD and this?????

There are several links with h. pylori and also others like adeno virus...

They wouldn't find gluten mal-adsorbtion if he's GF .....

Give me a call if you want a GP recommendation or two.....heck give me a call anyway :D but Im outrageously busy.. burned down my kitchen yesterday and currently repainting and plastering....

I hear a lots and lots of good things about doc Saltzman in the 9th... but I also hear you need a recommendation to get in.... I can find you one though :D no prob. and you are welcome to try my wonderful GI in the 5th.... she's an absolute angel and takes anyone (when I quit my job she gave me a lecture on how she would treat me for free and I should never not go because of the cost) ....

[jccgf]

They wouldn't find gluten mal-adsorbtion if he's GF .....
Steve, you make an excellent point! Thank you!

OMgoodness, you really had a fire in your kitchen???? I'm so sorry to hear that, and hope that nobody was hurt. Good luck in the remodel. Was the damage extensive?

Cara

[stevel]

Steve, you make an excellent point! Thank you!

OMgoodness, you really had a fire in your kitchen???? I'm so sorry to hear that, and hope that nobody was hurt. Good luck in the remodel. Was the damage extensive?

Cara

Nah... time wise yes I need to do a lot of cleaning.... for smoke damage (mostly done) and replastering where the ceiling peeled off (90% finished) and repaint the whole lot (oh and get this paint off my keyboard :D)

[KimS]

Glad you're okay Steve.

I was just reading, yesterday, how low iodine can be linked to high h.p. Maybe that could help some in your direction of research... as a matter of fact I'll start a new food study thread :D on it.

[Hanna]

They found it in his biopsy and not in his blood???? 2ndly, we eat alot of fish?????? Thanks

[Hanna]

My son is doing better. The docs here say his h pylori has caused his anemia?????? What are your professional opions:)

[jccgf]

My opinion isn't professional ;) , but yes, it is certainly possible that h. pylori could be a cause for his anemia.

That does not rule out the possibility that gluten sensitivity isn't also a contributing factor.

These things can co-exist and commonly do. Either or both conditions could result in anemia.

Cara

[KimS]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=helicobacter+pylori+celiac&tool=fuzzy&ot=helicobactor+pylori+celiac

Here's one on that search page that fits exactly (I think it's' the 9th one down). Maybe take this to his doctor...

Hershko C, Hoffbrand AV, Keret D, Souroujon M, Maschler I, Monselise Y, Lahad A. Related Articles, Links
Free Full Text Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia.
Haematologica. 2005 May;90(5):585-95.
PMID: 15921373 [PubMed - in process]

[annelb]

Good to hear that your son is doing better, Hanna.

Here is another abstract that links h. pylori to iron deficiency anemia. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16306309&dopt=Abstract
Am J Epidemiol. 2006 Jan 15;163(2):127-34. Epub 2005 Nov 23.

Iron deficiency and Helicobacter pylori infection in the United States.

Cardenas VM, Mulla ZD, Ortiz M, Graham DY.

Division of Epidemiology, University of Texas School of Public Health, El Paso, USA. victor.cardenas@uth.tmc.edu

Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and iron-deficiency anemia (IDA) in the United States. Iron deficiency was defined as at least two abnormal results out of three biomarkers of iron stores. IDA was defined as a low hemoglobin level in the presence of iron deficiency. H. pylori infection was measured by serology. Complex survey estimators were used in the analysis. For 7,462 survey participants aged >or=3 years, H. pylori infection was associated with decreased serum ferritin levels (percent change = -13.9%, 95% confidence interval (CI): -19.5, -8.0) but not with levels of free erythrocyte protoporphyrin, transferrin saturation, or hemoglobin (percent change = 1.5%, -2.8%, and -1.1%, respectively). Multinomial logistic regression analyses indicated that H. pylori infection was associated with the prevalence of IDA (prevalence odds ratio (POR) = 2.6, 95% CI: 1.5, 4.6) and, to a lesser degree, other types of anemia (POR = 1.3, 95% CI: 1.0, 1.7). H. pylori infection was associated with a 40% increase in the prevalence of iron deficiency (POR = 1.4, 95% CI: 0.9, 2.0) after controlling for relevant covariates. In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease.

PMID: 16306309 [PubMed - indexed for MEDLINE]

How is your son's B12 level?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12485119&dopt=Abstract
Helicobacter. 2002 Dec;7(6):337-41. Related Articles, Links
Click here to read
Impact of Helicobacter pylori on the development of vitamin B12 deficiency in the absence of gastric atrophy.

Serin E, Gumurdulu Y, Ozer B, Kayaselcuk F, Yilmaz U, Kocak R.

Department of Gastroenterology, Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Adana, Turkey.

BACKGROUND: Cobalamin (vitamin B12) deficiency is associated with Helicobacter pylori infection. This study examined how serum vitamin B12 levels relate to gastric mucosa H. pylori density and histology, and to hematological findings in patients with minimal or no gastric atrophy. A second aim was to confirm that H. pylori eradication therapy increases serum B12. MATERIALS AND METHODS: Biopsies of the gastric mucosa from a population of dyspeptic patients were graded for level of chronic inflammation, neutrophil activity, atrophy, and H. pylori density. A total of 145 H. pylori-infected patients with minimal or no atrophy were included in the study. Serum cobalamin level, hemoglobin level, and mean corpuscular volume were measured in the 145 patients before eradication therapy, and in 65 of the subjects after treatment. The hematologic findings before and after eradication therapy and correlations between serum vitamin B12 level and histologic parameters, hematologic findings, and patient age were statistically analyzed. RESULTS: There was no significant correlation between serum cobalamin level and patient age. Before treatment all the histopathological scores were inversely correlated with serum vitamin B12 level (p <.01) on univariate analysis. Only H. pylori density was significantly associated with B12 level on multivariate analysis. Serum hemoglobin and cobalamin levels were significantly increased after treatment, regardless of H. pylori eradication status (p <.001). CONCLUSION: The findings provide strong evidence that H. pylori infection is associated with cobalamin deficiency, and show that this is true even in patients with non-ulcer dyspepsia and minimal or no gastric atrophy.

PMID: 12485119 [PubMed - indexed for MEDLINE]