http://neurotalk.psychcentral.com en Wed, 16 May 2012 11:19:47 GMT vBulletin 30 http://neurotalk.psychcentral.com/images/ca_evo2/misc/rss.jpg http://neurotalk.psychcentral.com http://neurotalk.psychcentral.com/showthread.php?t=169830&goto=newpost Wed, 16 May 2012 03:59:39 GMT I came across this article tonight. It gives a person something to think about while we wait for the cure. It is a great thought I believe but I had... I came across this article tonight. It gives a person something to think about while we wait for the cure. It is a great thought I believe but I had PD for years before they ever did a colonoscopie
http://news.yahoo.com/early-signs-pa...224332356.html ]]> GregD http://neurotalk.psychcentral.com/showthread.php?t=169830 http://neurotalk.psychcentral.com/showthread.php?t=169818&goto=newpost Wed, 16 May 2012 00:14:58 GMT Hi there, I am interested in this therapy cycle for my Dad. Has anyone purchased one of these or know anything about it? ... Hi there,

I am interested in this therapy cycle for my Dad. Has anyone purchased one of these or know anything about it?

http://www.therapy-cycle.com/motorized-exp.html ]]> bubblyshar http://neurotalk.psychcentral.com/showthread.php?t=169818 http://neurotalk.psychcentral.com/showthread.php?t=169795&goto=newpost Tue, 15 May 2012 17:43:25 GMT I had a talk with Dr. Jennings (www.parkinsonstmj.com) who says that most PD is caused by trigeminal nerve dysfunction usually secondary to jaw... I had a talk with Dr. Jennings (www.parkinsonstmj.com) who says that most PD is caused by trigeminal nerve dysfunction usually secondary to jaw malalignment.
See http://www.dentalphysician.com/www07...dparadigm.html

The hypertonic nerve increases substance P that manifests in, among many other things, over activation of the microglial cells in the brain. So it is usually a bite disturbance that causes the brain inflammation that progresses PD.

Is the hypothesis accurate? If you search Youtube for Parkinson's tmj you will find several amazing videos. Here is one: http://www.youtube.com/watch?v=no0ifu7Yzo4

More can be found at www.tmjstack.com ]]> GerryW http://neurotalk.psychcentral.com/showthread.php?t=169795 http://neurotalk.psychcentral.com/showthread.php?t=169768&goto=newpost Tue, 15 May 2012 02:18:46 GMT (I did not know this. thought it was a holiday dreamed up by Hallmark, the flower industry and chocolate companies. madelyn) Mother’s Day began... (I did not know this. thought it was a holiday dreamed up by Hallmark, the flower industry and chocolate companies. madelyn)

Mother’s Day began in America in 1870 when Julia Ward Howe wrote the Mother’s Day Proclamation. Written in response to the American Civil War and the Franco-Prussian War, her proclamation called on women to use their position as mothers to influence society in fighting for an end to all wars. She called for women to stand up against the unjust violence of war through their roles as wife and mother, to protest the futility of their sons killing other mothers’ sons.
Howe wrote:
Arise, then, women of this day! Arise, all women who have hearts, Whether our baptism be of water or of tears!
Say firmly: “We will not have great questions decided by irrelevant agencies, our husbands will not come to us, reeking with carnage, for caresses and applause. Our sons shall not be taken from us to unlearn all that we have been able to teach them of charity, mercy and patience. We, the women of one country, will be too tender of those of another country to allow our sons to be trained to injure theirs.”
From the bosom of the devastated Earth a voice goes up with our own. It says: “Disarm! Disarm! The sword of murder is not the balance of justice.” Blood does not wipe out dishonor, nor violence indicate possession.
In the name of womanhood and humanity, I earnestly ask that a general congress of women without limit of nationality may be appointed …to promote the alliance of the different nationalities, the amicable settlement of international questions, the great and general interests of peace.

http://feministcampus.org/blog/index...f-mothers-day/ ]]> olsen http://neurotalk.psychcentral.com/showthread.php?t=169768 http://neurotalk.psychcentral.com/showthread.php?t=169724&goto=newpost Mon, 14 May 2012 13:27:03 GMT eOne question that has come up is how do toxins that we still encounter at chronic levels influence our progression or even how we feel. One of those... eOne question that has come up is how do toxins that we still encounter at chronic levels influence our progression or even how we feel. One of those things that is nearly impossible to control anymore is air pollution. One thing we can is eliminating BPA from our lives. As many already know, BPS mimics estrogen in our systems, but what we do not yet know is how profoundly it disrupts our estrogen homeostasis. This is rather important for us as researchers are just learning that estrogen has a big influence on dopamine levels and transmission, but it looks to alter glucose homeostasis in the pancreas. This can lead to Type II Diabetes.


Estrogen mimics at low doses change how brain cells manage dopamine.

Xenoestrogens and Diabetes

Incidence of Type II Diabetes has been soaring in the US but is dismissed as an outcome of poor diet. Maybe it is BPA? Also interesting to note links found between diabetes and PD. Could this be related to BPAs? When we hear BPS we think of plastic water bottles, but it is also used as lining in canned goods.

Don't count on the FDA to do an anything about it. They care first and foremost about chemical manufacturing profits or so it seems. It is mind boggling that they will consider only one flawed study (their own) as the gold standard on BPA. Sounds familiar in that they ignore all the research on Duodopa for example. All they do or fail to do seems linked to their own agenda. They reviewed the BPA situation in 2009 and again under lawsuit but hold fast that there is insufficient evidence; well when 90% of the populace has BPA readily detected in their blood stream, it doesn't bode well for research mandates a control group.

Further reading:

FDA 'Wrong' Not To Ban BPA, Health Advocates Say

Anyway would be interesting to look more closely at disease stats and the rise of BPA in our lifestyle of convenience.

Laura ]]> Conductor71 http://neurotalk.psychcentral.com/showthread.php?t=169724 http://neurotalk.psychcentral.com/showthread.php?t=169687&goto=newpost Sun, 13 May 2012 12:49:37 GMT My father has been a parkinsons patient for 7 years now. since he was 43. He has recently been overdosing on tablets, taking up to 1800mg a day... My father has been a parkinsons patient for 7 years now.

since he was 43.

He has recently been overdosing on tablets, taking up to 1800mg a day in sinemet, azilect, and sinemet cr

he had been self medicating not following doctors plans, and started to develop erratic and disturbing behaviour, doing irrational things, and feelings of paranoia.

the doctor has reduced his dosage to 1000mg a day , from 7am every 1 hours taking 100mg

however he has had 2 days where he has been off pretty much all day.

is there adjustment period for the body? ]]> arin http://neurotalk.psychcentral.com/showthread.php?t=169687 http://neurotalk.psychcentral.com/showthread.php?t=169686&goto=newpost Sun, 13 May 2012 12:01:13 GMT Non-Pharma research: here are some examples of research about Parkinson's and dance: part of the very small trickle of research looking for something other than a new flavor of agonist:
http://danceforparkinsons.org/resources/research ]]> Bob Dawson http://neurotalk.psychcentral.com/showthread.php?t=169686 http://neurotalk.psychcentral.com/showthread.php?t=169662&goto=newpost Sat, 12 May 2012 18:05:11 GMT "Physician, author, speaker, researcher, and consultant Martin L. Rossman, MD, discusses how to use the power of the healing mind to reduce stress and anxiety, relieve pain, change lifestyle habits, and live with more wellness"

http://www.youtube.com/watch?v=KYJde...feature=relmfu ]]> imark3000 http://neurotalk.psychcentral.com/showthread.php?t=169662 http://neurotalk.psychcentral.com/showthread.php?t=169655&goto=newpost Sat, 12 May 2012 13:44:04 GMT Do forum members know of any tables that show the equivalent doseages of common PD drugs? For instance, it would be useful to be able to know the... Do forum members know of any tables that show the equivalent doseages of common PD drugs?

For instance, it would be useful to be able to know the approximate effect of:
1 mg levodopa = x mg Sinemet
x mg Sinemet = y mg Stalevo, where x and y are the levodopa content
x mg ropinirole = y mg pramipexole

This information would be useful for anyone changing drugs.

It would also be useful in clinical trials and white ratting as a measurement tool by providing a common denominator, e.g. it would allow statements to be made like "this therapy has the same effect as x mg Sinemet".

Annoyingly, there is a paper on the subject [1], but this is behind a pay-wall.

The best reference I can find is a slide show, "Levodopa Dose Equivalency: A Systematic Review" [2], by Claire Smith, from the Clinical Trials Unit at Birmingham University, UK. This uses the concept of
"LED [levodopa equivalent dose] of a drug as that which produces same anti-parkinsonian effect as 100 mg of immediate release levodopa"

Levodopa (it's not clear whether this includes carbidopa, 1 mg) LED = 1
Stalevo (it's not clear how this value is calculated, 1 mg levodopa) LED = 1.33
Ropinirole (1 mg) LED = 20
Rasagiline (1 mg) LED = 100
(The slide show lists many other drug equivalences.)

From these figures a daily total levodopa can be calculated. For instance, in my case: rasagilene, 1 mg (LED 100); ropinirole, 16 mg (320); Stalevo 4x75 mg levodopa (400). Giving a total daily levodopa equivalent dose of 820 mg.

Please note that the numbers in the slide show are based on a literature review. The papers used are not all in agreement as to the conversion factors. Therefore, the values given above should be taken as estimates.

Also, note that different drugs work by different mechanisms and have different side effects and do not always scale linearly. So they should not be thought of as directly substitutable. For instance, [3] reports that there is little marginal benefit increasing the rasagiline dose above 1 mg.

[1] http://www.ncbi.nlm.nih.gov/pubmed/21069833
[2] http://www.pdmed.bham.ac.uk/investig...LED_Review.ppt
[3] http://dailymed.nlm.nih.gov/dailymed...rchiveid=10668

John ]]> johnt http://neurotalk.psychcentral.com/showthread.php?t=169655 http://neurotalk.psychcentral.com/showthread.php?t=169644&goto=newpost Sat, 12 May 2012 02:44:03 GMT Has anyone tried the generic for Stalevo, and if so, have you noticed any difference in how it works?:Ponder: Has anyone tried the generic for Stalevo, and if so, have you noticed any difference in how it works?:Ponder: ]]> JoClay http://neurotalk.psychcentral.com/showthread.php?t=169644 http://neurotalk.psychcentral.com/showthread.php?t=169635&goto=newpost Fri, 11 May 2012 23:16:35 GMT diagnosed with pd over 5 years ago. was put on sinemet cr 25/100. at the beginning of this year was up to 10 pills aday. i went from normal one day... diagnosed with pd over 5 years ago. was put on sinemet cr 25/100. at the beginning of this year was up to 10 pills aday. i went from normal one day to not being able to move the next. my dr wanted me to take more meds. i sought other advice and was told by several neurologists and a dat scan that i did not have pd. and that all i needed to do was to get off the meds. i tried but getting off a pill every 4 to 7 days put me in the er. i read once upon a pill which was the only resource i could find for my plight. i am currently down to 5 pills and the rollercoaster of symptoms continue. the only positive i have is the amount of pills has decreased. i am looking for testimonials of those in my similar situation that have gotten off it and how and how long did it take to get back to normal and are there any "tricks of the trade" out there that can help. i am doing the 10% reduction of meds as symptoms warrant. thanks for any input. ]]> ldopa http://neurotalk.psychcentral.com/showthread.php?t=169635 http://neurotalk.psychcentral.com/showthread.php?t=169628&goto=newpost Fri, 11 May 2012 22:02:54 GMT Vit K can help Parkinson's patients
http://www.irishhealth.com/article.html?id=20679

[Posted: Fri 11/05/2012 www.irishhealth.com]

By Caoimhe Moore

Administration of vitamin K2 could restore movement in Parkinson's patients.

Research has shown using vitamin K2 to reverse the effects of one of the genetic malfunctions that can lead to Parkinson's has given hope to Parkinson's patients.

Neuroscientist Patrik Verstreken, associated with the research institute VIB and KU Leuven university in Belgium, used fruit flies to study the mutation of a specific genetic pathway which can lead to Parkinson's.

Parkinson's is a neurodegenerative disease and the exact cause is unknown. The symptoms include lack of movement, hesitant speech, tremors and muscle stiffness.

The pathway studied regulates mitochondria, which transports electrons to the cell, providing the cell with energy. Mutation of the pathway can significantly lower the energy supply to the cell.

Lack of energy in a cell has serious consequences - parts of the brain will start to die and neuron communication will be disrupted.

Verstreken and his team found that vitamin K2 improved electron transport in the mitochondria. This in turn led to improved energy production.

Dr Versgtreken said therefore, it appeared that administering vitamin K2 could possibly help patients with Parkinson's. However, more work needed to be done to understand this better.

The study found that fruit flies became paralyzed when the PINK1 and Parkin pathway was mutated. Once the flies were given vitamin K2 their flying ability improved.

This research, it is believed, could potentially provide hope for new treatments for Parkinson's patients.

The study was published in the journal Scienc ]]> olsen http://neurotalk.psychcentral.com/showthread.php?t=169628 http://neurotalk.psychcentral.com/showthread.php?t=169626&goto=newpost Fri, 11 May 2012 21:55:20 GMT Suspected anti-Parkinson's gene spotted in 23andMe database

October 31, 2011 | By Ryan McBride

A genetic finding has triggered research that could lead to a new weapon against Parkinson's disease, a neurological disorder in dire need of new therapies. And the discovery has come from a somewhat non-traditional source: the vast personal genetics database of the private company 23andMe.

Mountain View, CA-based 23andMe made its discovery while building a relatively massive database of genetic information on Parkinson's patients, with more than 6,000 people with incurable disease involved in its program. About half of people who carry a mutation on the LRRK2 gene develop Parkinson's, but 23andMe's database showed there were many people with the mutation who don't have the disease. The common thread among these high-risk people who beat the odds was the gene SGK1, which researchers have theorized could protect people from the disease.



Read more: Suspected anti-Parkinson's gene spotted in 23andMe database - FierceBiotechIT http://www.fiercebiotechit.com/story...#ixzz1ubIZutTu
Subscribe: http://www.fiercebiotechit.com/signu...ierceBiotechIT

(sorry if a repost--I do not remember seeing this info about SGK1. madelyn) ]]> olsen http://neurotalk.psychcentral.com/showthread.php?t=169626 http://neurotalk.psychcentral.com/showthread.php?t=169624&goto=newpost Fri, 11 May 2012 21:45:18 GMT Google’s Brin Makes Strides in Hunt for Parkinson’s Cure ... Google’s Brin Makes Strides in Hunt for Parkinson’s Cure

http://www.bloomberg.com/news/2012-0...re-health.html ]]> olsen http://neurotalk.psychcentral.com/showthread.php?t=169624 http://neurotalk.psychcentral.com/showthread.php?t=169600&goto=newpost Fri, 11 May 2012 15:05:46 GMT Has there been other info about this? It sounds very promising.:D http://www.yissum.co.il/technologies/project/7-2006-138 7-2006-138 | L-DOPA... Has there been other info about this?
It sounds very promising.:D

http://www.yissum.co.il/technologies/project/7-2006-138

7-2006-138 | L-DOPA Amide Derivatives for Treating Parkinson’s Disease
Atlas Daphne, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences

Novel treatment for Parkinson’s disease overcomes “on-off” phenomenon

Development Stage

Concept proven, in vivo human models

Patent Status

Pending patent application in, Europe, US and Israel (PCT publication № WO2004/069146)

Highlights

Increases the endogenous level of dopamine to alleviate the motor complications of Parkinson’s disease and to delay the onset of the symptoms from the dramatic decrease in dopamine
Formulated for buccal, oral, sub-lingual, parenteral, intranasal, intramuscular, intravenous, subcutaneous, intraduodenal or rectal administration


Our Innovation

Provides a pharmaceutical preparation for the treatment of patients suffering from PD comprising a composition of L-Dopamide
A water-soluble compound could be applied f for rescue therapy. An advantage over the insoluble L-DOPA
Involves an essential structural change to make L-DOPA more soluble and resistant to DOPA Decarboxylase
Administrable without Carbidopa due to resistance to DOPA-decarboxylase
L-Dopamide is slowly hydrolyzed to L-DOPA because it is resistance to DOPA decarboxylase
Slow release addresses the on/off phenomenon of Parkinson’s
Degrades to natural products


The Opportunity

Addresses the need for more effective therapy for Parkinson’s disease using a more sustained level of dopamine

Oral results

Oral application in animal model showed longer duration > 40% over L- DOPA.

Higher efficiency as a proof of concept in experiments made side by side with L-DOPA
PK studies available

Development Milestones

Ready for toxicology studies.
Patent Status

Granted US 8,048,926
]]> VICTORIALOU http://neurotalk.psychcentral.com/showthread.php?t=169600