No that one can't be co-morbid (have more than one condition) in almost any situation, but those with neuron damage often have twitches, spasms, and/or feelings of banding, tightness, tension sensations of needing to move the legs (or arms, or hands) . . .actually moving the legs changes the sensation input and results in the reduction of these sensations, at least temporarily.
The thing to remember is that restless leg syndrome is just that, a syndrome, like many neuropathies are--it's not a disease in itself, but is caused by something else (perhaps nerve dysfunction), and there are many conditions that may mimic it (including neuropathic ones).
This Mayo Clinic site has a good summary: