White rat report. DXM as therapy.

[reverett123]

This really is something special. I will keep at it and bump this up from time to time.

[RLSmi]

Originally Posted by reverett123

This really is something special. I will keep at it and bump this up from time to time.

Rick; This is really great! Please do keep us updated on how things progress.

[reverett123]

DXM works on multiple levels. That is a little unusual for PD.
1. The low dose at bedtime, if I understand, works via manipulation of opioid receptors.
2. Anti-neuroinflammatory action works via the immune system.
3. BBB protection works through a route unknown to me
4. The amplification of dopaminergic circuits, which I'm exploring, seems to work via antagonism of the NMDA glutaminergic receptors. Why that makes such a difference in my capabilities I don't know. The important part is that NMDA antagonists make a positive change in PD symptoms. That is what happened when the PWP who was a former stuntman went to a concert with friends, took Ecstasy, and found that he could do acrobatics again.

Ecstasy is an NMDA antagonist as is PCP and a number of other illegal drugs. There are few such that do not have serious side effects. DXM is one. But there is one more.

Theamine is an amino acid found only in tea and one type of mushroom. It is also an NMDA antagonist and is the reason a cup of tea mellows you out while coffee sets you to buzzing. Japanese researchers have tried to determine the maximum safety level with no luck because it seems to have no toxicity.

If theamine works similar to DXM, then the problems of drug interactions, metabolic differences, and dosing all vanish. There isn't a lot of research on it and PD, but what that does exist is positive. And I switched to it from DXM last night and this morning and it does, indeed, seem to be doing the same way as DXM.

More as things develop.

[reverett123]

It wasn't an hour after that last post that I crashed into a strong Off similar to the "old days". It had been about 32 hours since the last DXM. During that 32 hours, I had taken 3 capsules of theanine at 100 mg each (2 yesterday and 1 today).

It was a deep Off but I took requip and sinemet and a qtr tsp of DXM and was back On in an hour. Much better than before.

So, what does that tell me? Theanine (T) can't substitute for DXM at the dosages I was using? That the DXM cleared my system in 32 hrs instead of four to six? That once stabilized on the DXM that it might be worth experimenting with T? (BTW, there was a nice little buzz with T )