Just posting this for the information of some of my TS friends who have, over many, many years now, been following the mecamylamine/inversine story.
Big Pharma's new drug has a twisted history
By Dr. Allan Spreen on 11/09/2011
Targacept Press Release
AstraZeneca and Targacept Announce First Top-line Phase 3 Results for TC-5214 as an Adjunct Treatment in Patients with Major Depressive Disorder
Wilmington, DE and Winston-Salem, NC
November 08, 2011
AstraZeneca and Targacept, Inc. today announced top-line results from the first of four RENAISSANCE Phase 3 studies investigating the efficacy and tolerability of TC-5214 as an adjunct therapy to an antidepressant in patients with major depressive disorder (MDD) who do not respond adequately to initial antidepressant treatment. The study did not meet its primary endpoint of change on the Montgomery-Asberg Depression Rating Scale (MADRS) after eight weeks of treatment with TC-5214 as compared to placebo.
AstraZeneca, Targacept drug fails depression test
By Ben Hirschler
LONDON | Tue Nov 8, 2011 3:17pm EST
TC-5214 is a tweaked version of mecamylamine, a drug introduced in the 1950s to treat high blood pressure.