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Unread 12-02-2011, 09:19 PM   #71
Lara
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Default Regarding Mecamylamine/Inversine etc.

Just posting this for the information of some of my TS friends who have, over many, many years now, been following the mecamylamine/inversine story.

http://www.healthiertalk.com/big-pha...d-history-4911

Big Pharma's new drug has a twisted history
By Dr. Allan Spreen on 11/09/2011

_______________

http://www.targacept.com/wt/page/pr_1320723633
Targacept Press Release
AstraZeneca and Targacept Announce First Top-line Phase 3 Results for TC-5214 as an Adjunct Treatment in Patients with Major Depressive Disorder

Wilmington, DE and Winston-Salem, NC

November 08, 2011

Quote:
AstraZeneca and Targacept, Inc. today announced top-line results from the first of four RENAISSANCE Phase 3 studies investigating the efficacy and tolerability of TC-5214 as an adjunct therapy to an antidepressant in patients with major depressive disorder (MDD) who do not respond adequately to initial antidepressant treatment. The study did not meet its primary endpoint of change on the Montgomery-Asberg Depression Rating Scale (MADRS) after eight weeks of treatment with TC-5214 as compared to placebo.
_______________

AstraZeneca, Targacept drug fails depression test
http://www.reuters.com/article/2011/...7A71KO20111108
Reuters
By Ben Hirschler
LONDON | Tue Nov 8, 2011 3:17pm EST

Quote:
TC-5214 is a tweaked version of mecamylamine, a drug introduced in the 1950s to treat high blood pressure.
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Last edited by Lara; 12-02-2011 at 09:37 PM.
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Unread 01-10-2012, 03:10 PM   #72
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Default Cautionary Note on Heat-Related Illness

Quote:
The following information is from the NYS Commission on Quality of Care and Advocacy for Persons with Disabilities. It was published in 2006, but is timeless advice for all of us, especially if we have family members or students on medications:
Cautionary Note on Heat-Related Illness
from Tourette Syndrome "Plus"
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Unread 03-17-2012, 05:58 PM   #73
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Book Toxoplasmosis

Quote:
Originally Posted by Lara View Post
<dead link removed>
A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii
Elizabeth A. Gaskell, Judith E. Smith, John W. Pinney, Dave R. Westhead, and Glenn A. McConkey

from PubMed Central

PLoS ONE. 2009; 4(3): e4801.
Published online 2009 March 11. doi: 10.1371/journal.pone.0004801.
Just adding on some information here.
NOTE: the first link in the old post no longer worked so I removed it.

Eur Child Adolesc Psychiatry. 2001 Sep;10(3):200-4.
Obsessive-compulsive disorder and acquired toxoplasmosis in two children.
Brynska A, Tomaszewicz-Libudzic E, Wolanczyk T.
http://www.ncbi.nlm.nih.gov/pubmed/11596821
PMID: 11596821

Eur Arch Psychiatry Clin Neurosci. 2010 Jun;260(4):359-63.
Epub 2009 Nov 5.
Association between intracellular infectious agents and Tourette's syndrome.
Krause D, Matz J, Weidinger E, Wagner J, Wildenauer A, Obermeier M, Riedel M, Mόller N.
http://www.ncbi.nlm.nih.gov/pubmed/19890596
PMID:19890596

Psychiatry Res. 2010 May 15;177(1-2):263-5.
Epub 2010 Jan 27.[b]
Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?
Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S.
http://www.ncbi.nlm.nih.gov/pubmed/20106536
PMID:20106536
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Last edited by Lara; 03-17-2012 at 06:40 PM.
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Unread 04-04-2012, 05:53 AM   #74
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Book Gilles De La Tourette syndrome: the current status.

Arch Dis Child Educ Pract Ed. 2012 Mar 22. [Epub ahead of print]
The Gilles De La Tourette syndrome: the current status.
Robertson MM.
http://www.ncbi.nlm.nih.gov/pubmed/22440810

Seems I have a lot to read. I might buy this full text actually. There are a lot of things stated by Prof Robertson in this abstract I'd like to understand more.

e.g.

Quote:
The most common comorbidities are attention deficit hyperactivity disorder, obsessive-compulsive behaviours, and disorder, and autistic spectrum disorders, while the most common coexisting psychopathologies are depression, anxiety and behavioural disorders such as oppositional defiant and conduct disorder.
Quote:
It is widely accepted that most cases of GTS are inherited, but the genetic mechanisms appear much more complex than previously understood, as evidenced by many recent studies; indeed, there have been suggestions of 'general neurodevelopmental genes' which affect the brain development after which the 'specific GTS gene(s)' may further affect the phenotype.
bold text added by me.
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Unread 04-04-2012, 06:05 AM   #75
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Confused

Genes Brain Behav. 2012 Mar 21. doi: 10.1111/j.1601-183X.2012.00778.x. [Epub ahead of print]
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette Syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/22435649
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Unread 04-04-2012, 06:08 AM   #76
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Exclamation Eye tics as core feature of GTS

J Neurol. 2012 Mar 21. [Epub ahead of print]
Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome.
Martino D, Cavanna AE, Robertson MM, Orth M.
http://www.ncbi.nlm.nih.gov/pubmed/22434162

Quote:
Our data confirm that eye and eyelid/eyebrow movement tics are very common in GTS, and most patients have several types of eye tics over time. Eye tic phenomenology was similar in patients with or without co-morbidity.
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Unread 04-04-2012, 06:11 AM   #77
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Default Headaches and migraines

J Pediatr. 2012 Mar 15. [Epub ahead of print]
Headache in Children with Tourette Syndrome.
Ghosh D, Rajan PV, Das D, Datta P, Rothner AD, Erenberg G.
http://www.ncbi.nlm.nih.gov/pubmed/22424951

Quote:
The rate of migraine headache within the TS group was found to be 4 times greater than that of the general pediatric population, as reported in the literature. In addition, the rate of tension-type headache was found to be more than 5 times greater than that of the general pediatric population.
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Unread 04-24-2012, 08:40 AM   #78
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Default Stereotypic movement disorder: easily missed.

PubMed

Dev Med Child Neurol. 2010 Aug;52(8):733-8. Epub 2010 Feb 24.
Stereotypic movement disorder: easily missed.
Freeman RD, Soltanifar A, Baer S.
Department of Psychiatry and Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada

Quote:
SMD occurs in children without ASD or intellectual disability. The generally favorable clinical course is largely due to a gradual increase in private expression of the movements. Severity of the stereotypy is associated with sensory differences and psychopathology. Differentiation of SMD from tics and ASD is important to avoid misdiagnosis and unnecessary treatment.
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Unread 04-08-2013, 02:33 PM   #79
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Default Immune System and Schizophrenia

Not regarding TS however these are very interesting findings regarding Schizophrenia and the Immune System. Just posting here because I think this could be relevant to a number of conditions. Just my thoughts.

UTI Far More Likely After Schizophrenia Relapse
By Traci Pedersen Associate News Editor
from PsychCentral

http://psychcentral.com/news/2013/04...pse/53514.html
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Unread 05-02-2013, 03:55 PM   #80
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Default Antibacteral Soap

Just FYI

Decades-old question: Is antibacterial soap safe?

Regarding Triclosan in Antibacterial soap.
From Yahoo
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