This vague reference in the link has been mentioned before. I am interested in deeper understanding. There is a tendency to get stuck in circular logic where there is never a starting point to the claims.
I know that antibiotics can reduce inflammation from osteo-arthritis by reducing the inflammation thought to be caused by minor infections in the damaged arthritic tissue.
If amantadine shows a difference in children but not adults, could it be that the adults have stronger, more developed immune systems that lessen the benefit of an anti-viral med?
The best I could find is this:
<Mechanism of Action: Parkinson's Disease
The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. Data from earlier animal studies suggest that SYMMETREL may have direct and indirect effects on dopamine neurons. More recent studies have demonstrated that amantadine is a weak, non-competitive NMDA receptor antagonist (Ki = 10µM). Although amantadine has not been shown to possess direct anticholinergic activity in animal studies, clinically, it exhibits anticholinergic-like side effects such as dry mouth, urinary retention, and constipation.>
Other research suggests that anticholinergic meds should be avoided for PCS.
The comments about amantadine shows the improvements are marginal. I wonder if prescribing amantadine is more of a feel good effort that real therapeutic value. At least the patient will have less risk of contracting influenza A.
Mark in Idaho
59 years old, retired due to disability, married 34 years, father of three, grandfather of four, Suffered a serious concussion at 10 years old (1965) stopped most driving after concussion at 46 years old (2001), Post Concussion Syndrome/Multiple Concussion/Impact Syndrome with PTSD, immediate/short term visual and auditory memory problems, slowed processing speed, visual/auditory processing difficulties, insomnia, absence seizures, OCD, 14 concussions since first concussion at 8 years old, Taking paroxetine for 14 years and gabapentin for 12 years. Added L-Tryptophan and stopped paroxetine after 3 months of tapering. I currently take 500 mgs of L-Tryptophan AM, 500 mgs noon, and 500 mgs PM.
As of Nov 15th, Due to high stress issues resulting in PTSD, docs put me on 3 meds. Clonazepam but only for 30 days ) .125 mgs twice daily (Doc presc. .25 mgs 2x daily but half a tablet is good) , citalopram (Celexa), an SSRI , and olanzapine (Zyprexa), an atypical anti-psychotic that usually causes weight gain before bed. I lost over 30 pounds since mid July. It just stopped the weight loss. Took me off the gabapentin. I am feeling better than I have in years.
This great feeling only lasted a month. Back to the same old PCS doldrums.
May 2014, I am off the olanzapine due to a 6 fold price increase. Back on 600 mgs of gabapentin before bed.
I am also taking L-Theanine to help with GABA regulation
"Be Still and Know That I am God" Psalm 46:10