1. Mol Nutr Food Res. 2006 Feb;50(2):229-34.
Green tea catechins as brain-permeable, natural iron chelators-antioxidants for
the treatment of neurodegenerative disorders.
Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MB.
Eve Topf, Haifa, Israel. email@example.com
Neurodegeneration in Parkinson's, Alzheimer's, or other neurodegenerative
diseases appears to be multifactorial, where a complex set of toxic reactions,
including oxidative stress (OS), inflammation, reduced expression of trophic
factors, and accumulation of protein aggregates, lead to the demise of neurons.
One of the prominent pathological features is the abnormal accumulation of iron
on top of the dying neurons and in the surrounding microglia. The capacity of
free iron to enhance and promote the generation of toxic reactive oxygen radicals
has been discussed numerous times. The observations that iron induces aggregation
of inert alpha-synuclein and beta-amyloid peptides to toxic aggregates
reinforced the critical role of iron in OS-induced pathogenesis of
neurodegeneration, supporting the notion that a combination of iron chelation and
antioxidant therapy may be one significant approach for neuroprotection. Tea
flavonoids (catechins) have been reported to possess divalent metal chelating,
antioxidant, and anti-inflammatory activities, to penetrate the brain barrier and
to protect neuronal death in a wide array of cellular and animal models of
neurological diseases. This review aims to shed light on the multipharmacological
neuroprotective activities of green tea catechins with special emphasis on their
brain-permeable, nontoxic, transitional metal (iron and
copper)-chelatable/radical scavenger properties.
PMID: 16470637 [PubMed - indexed for MEDLINE]