Originally Posted by Conductor71
This is by the same guy who offers amino acid treatments in conjunction with levodopa therapy.
It is interesting given no one knows how DBS works and that electo convulsive therapy and magnetic resonators work for us. Here is perhaps why?
The etiology of chronic problems is not low concentrations of monoamines that need to be returned to normal as predicted by the monoamine hypothesis; it is concentrations that are normal but not high enough to compensate for postsynaptic neuronal damage. Addressing this electrical defect properly requires the system to be placed into the competitive inhibition state in order to be able to increase monoamine levels to above normal to reach the threshold level needed to establish the adequate electrical flow required.
This paper does try to sell his neurotransmitter balance based therapy...still this seems entirely plausible to me. Anyone else?
Maybe it's too early, but I don't get this. What I read these guys to be saying is that there is a problem with getting the dopamine to where it needs to be, because a bundle of neurons are impaired in some way, either by trauma (concussion, etc.), neurotoxin exposure (pesticides, etc.), biogenics, there are more than a few causes according to the authors. OK, I get that, they are saying PWP have enough dopamine, it's just not getting to where it needs to be...so giving levodopa does not help long-term.
I see their position that just giving one monoamine precursor will not help, as the neurotransmitters must all be in balance. So does that mean they think if we took precursors for several different monoamines, and therefore brought them into perfect balance, PD would disappear? This assumes, of course, that the perfect balance is the same for everyone, which I personally don't buy. Maybe they posit that we must all take supplements to find that perfect balance for ourselves, which I could see. Maybe I need 200mg 5-HTP but you need 750, we would just have to experiment individually to see what our own optimal balance would be.
But this is where I get confused...then at the same time they advocate giving supplements that are precursors to the monoamines? So if there is a physical problem in the transport highway, how does giving supplements help? They still can't go where they need to, even after they have been
synthsized by the body and made into the monoamines. What am I missing?