Help interpreting test results

[glenntaj]

--the IgA figure is for TOTAL IgA, that is well within reference range, and therefore the IgA transglutaminase figure of 3 is low and not an immediate indicator of celiac.

The tranglutaminase IgA is the blood test most closely associated with villous damage of frank celiac, but did they also test you for the IgA and IgG anti-gliadin antibodies (which are measures that are more sensitive, but less specific, and often will show in those with gluten sensitivity that is not, or at least not yet, causing noticeable intestinal damage)?

[ginnie]

The test should be administered for the best results, before the glutton free diet. ginnie

[Needananswer]

You can also ask your doctor to run the genetic test, if you haven't already. It is usually not covered by insurance but it helped confirm my dx. Good luck!

[pabb]

that particular test is neg, however doesn't mean you don't have celiac.

[Needananswer]

Originally Posted by pabb

that particular test is neg, however doesn't mean you don't have celiac.

It is virtually impossible to have celiac unless you carry the HLA gene. The antibodies can be negative but it would be highly unusual (if ever) to not have the gene.

[glenntaj]

--the genes may not only include the HLA-DQ2 and DQ8 variants that are quoted by most old-line researchers.

As Cara has documented in the Gluten File, European researchers, particularly Dr. Hadijvassiliou, have evidence pointing to other genetic configurations, particularly the HLA-DQ1 subtype, as predisposing towards gluten sensitivity, with or without frank celiac, and this may often manifest neurologically rather than gastrointestinally.