Welcome to Neuro Talk. None of us are doctors, but quite a few on this site have some real knowledge. Of course you are frightenend for your daughter. Topomax, I am not that familiar with in regards to headaches. What she is experiencing sounds like cluster migraines. I say that, as my neighbor experiences that as well.
I would try two things, a teaching hospital, or a doctor called a physiatrist. This type of specialist, deals with cronic pain, and the WHOLE body on a cellular level. This was who I found, and got the greatest amount of relief from my own disorders. I got help with pain, and started the road to recovery.
Please don't stop seeking answers. She is on a lot of different medications, and they should be looked at, to make sure there are no drug interactions to make matters worse. Someone will be along I am sure to talk about topomax in particular. Please feel free to ask all the questions you want. Most of us are not professionals, but have listened to many others on this site who have experienced conditions. alot of us do research, so we can help folks. Feel at home here, and know that this site will help you while you find some answers for your daughter. I wish both of you all the best, and hope you can find some solutions. ginnie