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Parkinson's disease protein found in intestinal wall

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Unread 11-17-2012, 01:15 AM   #1
soccertese
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Default Parkinson's disease protein found in intestinal wall

http://abclocal.go.com/kabc/story?se...lth&id=8888789
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Unread 11-17-2012, 02:31 AM   #2
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Thls could prove to be fantastic please help follow it
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Unread 11-17-2012, 09:45 AM   #3
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Default what is the protein?

Is the protein identified? thanks, madelyn
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Unread 11-17-2012, 10:22 AM   #4
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Default more detail and interview with researcer - Alpha-synuclein

Dr. Shannon: Right. We have a small group of patients with Parkinson's disease, 10 with very early Parkinson's disease, and then we compared them to 23 people who do not have Parkinson's disease. We only found the protein in the people who do have Parkinson's disease and we found that in every one of the people with Parkinson's disease.

http://www.newschannel5.com/story/20...-to-parkinsons
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Unread 11-17-2012, 10:26 AM   #5
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Default it is alpha-syn

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Originally Posted by olsen View Post
Is the protein identified? thanks, madelyn
earch Article
Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease†‡§

Kathleen M. Shannon MD1,*,
Ali Keshavarzian MD2,
Ece Mutlu MD2,
Hemraj B. Dodiya MS3,
Delia Daian2,
Jean A. Jaglin RN1,
Jeffrey H. Kordower PhD3

Article first published online: 15 JUL 2011

DOI: 10.1002/mds.23838

Copyright © 2011 Movement Disorder Society

Issue
Movement Disorders
Movement Disorders

Volume 27, Issue 6, pages 709–715, May 2012

Additional Information(Show All)

How to CiteAuthor InformationPublication History



Funding agencies: The study was supported in part by a research grant from Mr. and Mrs. Larry Field and by the Parkinson Disease Foundation.


Relevant conflicts of interest/financial disclosures: Nothing to report.
§

Full financial disclosures and author roles may be found in the online version of this article.

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Unread 11-17-2012, 03:25 PM   #6
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Default "Late in the game"

Quote:
Originally Posted by soccertese View Post
Dr. Shannon: Right. We have a small group of patients with Parkinson's disease, 10 with very early Parkinson's disease, and then we compared them to 23 people who do not have Parkinson's disease. We only found the protein in the people who do have Parkinson's disease and we found that in every one of the people with Parkinson's disease.

http://www.newschannel5.com/story/20...-to-parkinsons
According to what Dr Shannon said in the interview, once the protein gets into brain, it is "late in the game". So, what is the real hope for us?
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Unread 11-17-2012, 04:40 PM   #7
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Quote:
Originally Posted by wxxu View Post
According to what Dr Shannon said in the interview, once the protein gets into brain, it is "late in the game". So, what is the real hope for us?
keep an eye on these 2 companies for a start
http://ceregene.com/science_parkinsons.asp
prosavin, pg 17
http://www.parkinsonsmovement.com/wp...ue-2-final.pdf

nothing close to being available though. but as cliche as it sounds, the research is advancing by leaps and bounds. am i hopeful in my 12th year for something better than duodopa or dbs before i'm too old?? yes. so one has to live their life and take care of themselves the best they can so they can get whatever that "cure" may be.

they've already proven with foetal implants that in the best outcomes, the patient will experience sig. improvement for years. the procedure had some terrible outcomes and because of that and the ethics of using aborted fetuses, research was stopped. but don't let anyone tell you advanced pd'ers can't be helped by cell implants, they have been. at least that's been my understanding.
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Unread 11-17-2012, 08:58 PM   #8
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Default travel mechanism?

So how does the a-syn get out of the gut into the brain, past the bbb?
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Unread 11-17-2012, 10:40 PM   #9
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LFAC,
I've think people like Braak have suggested retrograde transport via nerves connecting the gut and brainstem such as the vagus. Also, movement between cells prion-like may be involved (e.g. across synapses; post-to-pre). Lewy bodies are already inside the BBB in gut ganglia.
Perhaps the real mystery is ...What causes aggregated alpha-syn to form in those ganglia in the first place?
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Unread 11-17-2012, 10:43 PM   #10
wxxu
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Default AFFiRi AG's Vaccine & QR Pharma's Posiphen?

Quote:
Originally Posted by soccertese View Post
keep an eye on these 2 companies for a start
http://ceregene.com/science_parkinsons.asp
prosavin, pg 17
http://www.parkinsonsmovement.com/wp...ue-2-final.pdf

nothing close to being available though. but as cliche as it sounds, the research is advancing by leaps and bounds. am i hopeful in my 12th year for something better than duodopa or dbs before i'm too old?? yes. so one has to live their life and take care of themselves the best they can so they can get whatever that "cure" may be.

they've already proven with foetal implants that in the best outcomes, the patient will experience sig. improvement for years. the procedure had some terrible outcomes and because of that and the ethics of using aborted fetuses, research was stopped. but don't let anyone tell you advanced pd'ers can't be helped by cell implants, they have been. at least that's been my understanding.
Thank you for this - I really like your optimism. I think this is why we are here together in this community. There is no doubt that this study will bring the PD researchers' community one large step further to solving this puzzle and finding better treatments (even if not a cure at the moment). Especially when looking together with Misfolded Protein Transmits From Cell To Cell by researchers at U Penn (you posted a few days ago), AFFiRi AG's phase one vaccine trial in June and QR Pharma's compound Posiphen, it tells that now is a better chance than ever to make some progress which has not been seen in past 40 more years.

Do you still remember not long ago AFFiRi AG's vaccine and also QR Pharma's Posiphen? At first the intestinal link was just an assumption, now, it is a "dream"(bad dream or a nightmare) comes true. But I have not heard about their trials ever since then, as I think they should in some way work together. From my internet readings, I have a feeling that researchers may not talk to each other and collaboration is limited. Many exchanges are only made at seminars or annual conferences where you possibly only have a small slice of time... On the other hand I think MJFF did great job as to fund all these studies, or this may still be a "dream" till now...
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