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Help interpreting test results

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Unread 11-03-2012, 06:01 AM   #11
glenntaj
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--the IgA figure is for TOTAL IgA, that is well within reference range, and therefore the IgA transglutaminase figure of 3 is low and not an immediate indicator of celiac.

The tranglutaminase IgA is the blood test most closely associated with villous damage of frank celiac, but did they also test you for the IgA and IgG anti-gliadin antibodies (which are measures that are more sensitive, but less specific, and often will show in those with gluten sensitivity that is not, or at least not yet, causing noticeable intestinal damage)?
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Unread 11-03-2012, 03:31 PM   #12
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The test should be administered for the best results, before the glutton free diet. ginnie
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Unread 11-04-2012, 06:05 PM   #13
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You can also ask your doctor to run the genetic test, if you haven't already. It is usually not covered by insurance but it helped confirm my dx. Good luck!
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Unread 11-05-2012, 12:06 PM   #14
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that particular test is neg, however doesn't mean you don't have celiac.
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Unread 11-27-2012, 08:15 PM   #15
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Quote:
Originally Posted by pabb View Post
that particular test is neg, however doesn't mean you don't have celiac.
It is virtually impossible to have celiac unless you carry the HLA gene. The antibodies can be negative but it would be highly unusual (if ever) to not have the gene.
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Unread 11-28-2012, 06:43 AM   #16
glenntaj
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--the genes may not only include the HLA-DQ2 and DQ8 variants that are quoted by most old-line researchers.

As Cara has documented in the Gluten File, European researchers, particularly Dr. Hadijvassiliou, have evidence pointing to other genetic configurations, particularly the HLA-DQ1 subtype, as predisposing towards gluten sensitivity, with or without frank celiac, and this may often manifest neurologically rather than gastrointestinally.
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Unread 12-10-2013, 02:43 AM   #17
JamieDuncan
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Default Help with interpreting test results

Hi
I recently had a gluten test done to see if I am allergic to gluten. The results are as follows:

> TTG IgA 0.70 0.00-10.0 U/mL
TTG IgA is the most sensitive and specific test for Celiac
disease (Gluten sensitivity). If there is still a high
degree of clinical suspicion in this patient, please exclude
IgA deficiency. In IgA deficient patients TTG IgG should be
done. The antigliadin and anti-endomycium antibodies
are also available if further testing is required.

Can someone please help with letting me know what the results mean.
Thanks
Jamie
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Unread 12-10-2013, 07:36 AM   #18
pabb
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Quote:
Originally Posted by JamieDuncan View Post
Hi
I recently had a gluten test done to see if I am allergic to gluten. The results are as follows:

> TTG IgA 0.70 0.00-10.0 U/mL
TTG IgA is the most sensitive and specific test for Celiac
disease (Gluten sensitivity). If there is still a high
degree of clinical suspicion in this patient, please exclude
IgA deficiency. In IgA deficient patients TTG IgG should be
done. The antigliadin and anti-endomycium antibodies
are also available if further testing is required.

Can someone please help with letting me know what the results mean.
Thanks
Jamie
Jamie, you do understand that celiac is not an allergy?
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Unread 12-14-2013, 07:23 PM   #19
Heinzelman
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Default Test Results

I have Celiac Disease & Hypothyroidism and have been gluten free for about 3 months. I had some tests ran and was wondering if someone could explain to me the results.
FERRITIN
FERRITIN 148 ng/mL 12/5/2013

TISSUE TRANSGLUT. AB, IgA
TISSUE TRANSGLUT. AB, IgA 22.5 AU/mL 12/5/2013
TTA INTERPRETATION Positive (>16.0 AU/mL) 12/5/2013

TSH
TSH 2.55 mIU/L 12/5/2013

IRON AND IRON BINDING CAP.
% TRANSFERRIN SATURATION 22 % 12/5/2013
IRON 100 ug/dL 12/5/2013
TOT. IRON BINDING CAPACITY 450 ug/dL 12/5/2013

25 HYDROXY VITAMIN D
25-HYDROXY VITAMIN D 25 ng/mL 12/5/2013
INTERPRETATION REFERENCE VALUES: 12/5/2013
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Unread 12-15-2013, 06:43 AM   #20
glenntaj
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Default Well, without the reference values--

--for the ferritin, iron binding capacity and Vitamin D, it's not easy . . .

Fortunately, I am familiar with the general reference ranges for these tests, and can say that the ferritin result depends on gender; if you are male that results is fairly well within range, but it female it is a little high. Similarly, your iron levels are pretty mid range, but the total iron binding capacity is very near the upper end of "normal" range, and the transferrin saturation is near the lower end of normal, especially, again, if you are male. This implies there is sufficient iron available but it is not being absorbed as efficiently as it could be.

You vitamin D levels would be considered low, and, of course, the anti-transglutaminase igA antibody levels are consistent with celiac disease.

The TSH is pretty much normal, but it would be more interesting if you had other TSH levels from the past to compare it with, to see if it has been gradually rising/falling or been pretty consistent.
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