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Tissue Transglutaminase IGG very high though not Celiac

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Unread 12-27-2012, 01:05 AM   #1
SusieA
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Default Tissue Transglutaminase IGG very high though not Celiac

Does anyone know what medical conditions (other than Celiac) are associated with high Tissue Transglutaminase, IGG levels? Mine were 25 and 33, (Negative = <7), two different labs. My IGA level is <3, (negative = <5) on both labs. I tested negative for Celiac via intestinal biopsy.
What else can cause high IGG levels? I also have Primary Hyperaldosteronism, Chronic Epstein Barr Virus which reactivates often, have tested positive for Mycoplasma Pneumoniae, and HHV6. I have chronic migraines and very low energy. Headaches and energy issues are so critical that I spend many days in bed. Just had a spinal tap, ordered by the neurologist & waiting on results. Anyway, doctors don't seem concerned about the HIGH TTG Antibody, IGG. I'm thinking it's not a good thing and would appreciate any feedback. When I search this topic I only see 'Celiac' articles. Thank you!

SusieA
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Unread 12-27-2012, 07:10 AM   #2
glenntaj
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Default Though there are some situations--

--in which an isolated elevated transglutaminase IgG level might be associated with other autoimmune conditions, it is still most likely to point to either developing celiac or non-celiac gluten sensitivity.

The Gluten File in the Useful Websites section of this very forum has a lot of information on this and on celiac in general (and is very nicely indexed).

There is ALSO the possibility that the biopsied simply weren't taken from places that are experiencing villious atrophy, which can be patchy and widespread, especially in the early stages of celiac. If the high titres and/or symptoms persist you may want to get another intestinal biopsy at some point. (What's also important to point out is that doctors, even gastroenterologists, vary greatly in their biopsy skills.)
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Unread 12-30-2012, 12:32 AM   #3
SusieA
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Originally Posted by glenntaj View Post
--in which an isolated elevated transglutaminase IgG level might be associated with other autoimmune conditions, it is still most likely to point to either developing celiac or non-celiac gluten sensitivity.

The Gluten File in the Useful Websites section of this very forum has a lot of information on this and on celiac in general (and is very nicely indexed).

There is ALSO the possibility that the biopsied simply weren't taken from places that are experiencing villious atrophy, which can be patchy and widespread, especially in the early stages of celiac. If the high titres and/or symptoms persist you may want to get another intestinal biopsy at some point. (What's also important to point out is that doctors, even gastroenterologists, vary greatly in their biopsy skills.)
Glenntaj,
Thank you so much for this information. I don't have any of the celiac symptoms just yet, as far as I know. I do have constant/chronic migraines but that's about it. My GP told me, just last Thurs, that the gall bladder can cause high Tissue Transglutaminase, IGG levels. At the time the biopsy was done I had not yet had my malfunctioning gall bladder removed (biopsy was done about 2 yrs prior to gall bladder removal). Soooo...I'm wondering if the high IGG level could have been gall bladder related. You are so right about different doctors being better at biopsying than others. I do remember the results from the biopsy describing "patchy areas". I should probably have another biopsy done, as you suggest. I look forward to reading the articles you mention in this forum. Thanks again for your very helpful input!

Take care,
Susie
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