For what it is worth-
1) Melissa inhibits cholinesterase, an enzyme.
Phytomedicine. 2012 Jun 15;19(8-9):836-9. doi: 10.1016/j.phymed.2012.03.010. Epub
2012 Apr 15.
Inhibition of cholinesterase by essential oil from food plant.
Chaiyana W, Okonogi S.
Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Inhibition of cholinesterase has attracted much attention recently because of its
potential for the treatment of Alzheimer's disease. In this work, the
anticholinesterase activities of plant oils were investigated using Ellman's
colorimetric method. The results indicate that essential oils obtained from
Melissa officinalis leaf and Citrus aurantifolia leaf showed high
acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. C
aurantifolia leaf oil revealed in this study has an IC(50) value on
acetylcholinesterase and butyrylcholinesterase of 139 ± 35 and 42 ± 5 μg/ml,
respectively. GC/MS analysis revealed that the major constituents of C.
aurantifolia leaf oil are monoterpenoids including limonene, l-camphor,
citronellol, o-cymene and 1,8-cineole.
Copyright © 2012 Elsevier GmbH. All rights reserved.
PMID: 22510493 [PubMed - indexed for MEDLINE]
2) Apr 5, 2011 | By Leigh Wittman
Cholinesterase is an enzyme that aids in motor control. This enzyme is manufactured in the liver and red blood cells. Cholinesterase-inhibitors are sometimes used to manage Parkinson's disease symptoms.
Although these medications tend to increase cognitive function, they also increase tremors and decrease motor control. Managing Parkinson's disease symptoms is a balancing act of managing cholinesterase levels.
Consult your physician prior to taking any measures to increase your cholinesterase levels, as doing so may seriously impact your Parkinson's disease treatment.