Go Back   NeuroTalk Support Groups > Health Conditions M - Z > Parkinson's Disease

Parkinson's Disease Tulip

The pathophysiology of tremor

Reply
Thread Tools Display Modes
Unread 01-15-2013, 12:12 AM   #1
Lemonlime
Junior Member
 
Join Date: Nov 2012
Location: Atlanta, GA
Posts: 39
Default The pathophysiology of tremor

This is an Interesting paper that addresses a lot of questions about tremor and it's free.

http://www.epda.eu.com/en/research-p...11-01-brain-1/


CEREBRAL CAUSES AND CONSEQUENCES OF PARKINSONIAN RESTING TREMOR: A TALE OF TWO CIRCUITS?

November 2012
Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR

Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in only three out of four patients with Parkinson's disease, and tremor-dominant patients generally follow a more benign disease course than non-tremor patients.

Pathophysiologically, tremor is linked to altered activity in not one, but two distinct circuits: the basal ganglia, which are primarily affected by dopamine depletion in Parkinson's disease, and the cerebello-thalamo-cortical circuit, which is also involved in many other tremors.

The purpose of this review is to integrate these clinical and pathophysiological features of tremor in Parkinson's disease. We first describe clinical and pathological differences between tremor-dominant and non-tremor Parkinson's disease subtypes, and then summarize recent studies on the pathophysiology of tremor. We also discuss a newly proposed ‘dimmer-switch model’ that explains tremor as resulting from the combined actions of two circuits: the basal ganglia that trigger tremor episodes and the cerebello-thalamo-cortical circuit that produces the tremor.

Finally, we address several important open questions: why resting tremor stops during voluntary movements, why it has a variable response to dopaminergic treatment, why it indicates a benign Parkinson's disease subtype and why its expression decreases with disease progression.


Access to paper
http://brain.oxfordjournals.org/cont.../3206.full.pdf



Post mortem studies in Parkinson's disease--is it possible to detect brain areas for specific symptoms?
http://www.ncbi.nlm.nih.gov/pubmed/10370901
Lemonlime is online now   Reply With Quote
"Thanks for this!" says:
johnt (01-15-2013), lurkingforacure (01-15-2013), Peony (01-22-2013), VICTORIALOU (01-15-2013)
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Anyone have a tremor? nightnurse30 Traumatic Brain Injury and Post Concussion Syndrome 16 11-20-2012 03:34 PM
Headache-"Pathophysiology & Treatments.... pono Headache 2 10-10-2012 01:34 AM
Pathophysiology of the systemic inflammatory response after major accidental trauma Sandel Reflex Sympathetic Dystrophy (RSD and CRPS) 2 11-18-2009 01:57 PM
Microcirculation Pathophysiology in CRPS buckwheat Reflex Sympathetic Dystrophy (RSD and CRPS) 0 02-07-2007 10:11 PM
Fibromyalgia Syndrome: New Developments in Pathophysiology and Management firemonkey Fibromyalgia and Chronic Fatigue 1 11-20-2006 10:03 AM


All times are GMT -5. The time now is 03:10 AM.
Brought to you by the fine folks who publish mental health and psychology information at Psych CentralMental Health Forums

The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider. Always consult your doctor before trying anything you read here.


Powered by vBulletin • Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.


All posts copyright their original authors • Community GuidelinesTerms of UsePrivacy Policy
NeuroTalk Archives