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Deamidated gliagin IgG the only test to come back positive, can you help?

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Unread 01-21-2013, 02:37 PM   #1
Jen_1984
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Default Deamidated gliagin IgG the only test to come back positive, can you help?

Hi, I have been experiencing for over 6 years some strange symptoms that seem to baffle my doctors and frustrate them and me. Recently, my neurologist ran a panel of blood tests and only two came back a little weird. One was the ant dsDNA and that one was in very low titer range of 1:10 and the deamidated gliadin peptide test which came back at 24 which is a weak positive range, 30 and above being in the strong positive range. My doc is convinced that I do not have lupus at all due to the low titers of the dsDNA and no rashes or arthritic body pains and he never mentioned anyhting about the deamidated gliadin peptide test. I am a little confused bu this test, as I had no idea what it even eant until I googled it and it said that it correlated with celiac disease... I had the deamidated gliadin peptide IgA which came back at 4 in the normal range, Ttg, which is normal. I am just wondering with a positive result on the deamidated gliadin igG do I have any business investigating celaic or gluten sensitivity or can this test indicate other diseases? Any input is very welcome, and thanks in advance.
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Unread 01-22-2013, 07:52 AM   #2
glenntaj
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Default Yes--you probably should do further investigations

--although, according to much of the research, the IgG anti-gliadin test is the most sensitive, but least specific, test for gluten problems. People with isolated raised anti-gliadin IgG titres without rasied anti-gliadin igA titres or antitransglutaminase titres are less likely to show frank celiac with villious atrophy and more likely to show gluten sensitivity.

The Gluten file, jcc's compendium of information on all things gluten (which is linked to at the the top of this forum under 'useful websites'), helps to explain this and a lot more (in particular, look for the work of Dr. Hadijvassiliou).
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Unread 03-13-2013, 04:36 PM   #3
veggienft
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The immune system uses IgA leukocytes (white blood cells) to operate on mucous membranes, including the membrane lining the intestines. The immune system uses IgG leukocytes to operate in the bloodstream. When the immune system perceives that a particular protein sequence is an attacking antigen it creates antibodies against the antigen and creates antibodies against the affected tissue. Your positive test result for IgG antibodies to gliadin means the body has identified wheat gliadin as an attacking antigen in your blood. What tissue is gliadin attacking? Among the anti-tissue antibodies your test tested for, none were identified. Does this mean your immune system is not making antibodies against one of your tissues? No. Your immune system is more than likely attacking one of hundreds of types of tissue. But your doctor did not test for the specific antibody. Why would I say this? Because your body has definitely recognized gliadin as an attacking antigen. You could run tests for every antibody sequence available and still not identify the target, because medical science hasn't scratched the surface of this devil.

But this doesn't matter. You know you are sustaining an autoimmune attack when you eat grassy grains. The answer is simple. Stop eating them.
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Unread 04-09-2013, 02:17 PM   #4
northernlights
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DGP IgG is very very specific for celiac, much more than DGP IgA. This is different from the old antigliadin IgG test.

Nora
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