This vague reference in the link has been mentioned before. I am interested in deeper understanding. There is a tendency to get stuck in circular logic where there is never a starting point to the claims.
I know that antibiotics can reduce inflammation from osteo-arthritis by reducing the inflammation thought to be caused by minor infections in the damaged arthritic tissue.
If amantadine shows a difference in children but not adults, could it be that the adults have stronger, more developed immune systems that lessen the benefit of an anti-viral med?
The best I could find is this:
<Mechanism of Action: Parkinson's Disease
The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. Data from earlier animal studies suggest that SYMMETREL may have direct and indirect effects on dopamine neurons. More recent studies have demonstrated that amantadine is a weak, non-competitive NMDA receptor antagonist (Ki = 10µM). Although amantadine has not been shown to possess direct anticholinergic activity in animal studies, clinically, it exhibits anticholinergic-like side effects such as dry mouth, urinary retention, and constipation.>
Other research suggests that anticholinergic meds should be avoided for PCS.
The comments about amantadine shows the improvements are marginal. I wonder if prescribing amantadine is more of a feel good effort that real therapeutic value. At least the patient will have less risk of contracting influenza A.
Mark in Idaho
58 years old, retired due to disability, married 33 years, father of three, grandfather of four, Suffered a serious concussion at 10 years old (1965) stopped most driving after last concussion at 46 years old (2001), Post Concussion Syndrome/Multiple Concussion/Impact Syndrome with PTSD, immediate and short term visual and auditory memory problems, slowed processing speed, visual and auditory processing difficulties, insomnia, absence seizures, OCD, 14 concussions since first concussion at 8 years old, Taking paroxetine and gabapentin for 12 years. Added L-Tryptophan and reduced paroxetine by half 3/2013
"Be Still and Know That I am God" Psalm 46:10