Chinese skullcap should be a powerhouse. Depends on what you think are the causes of PD and what is happening beneath the surface.
If you believe, as I do, that there is a hell of a lot more going on than we are taught to believe, then the center of the stage is taken up by inflammation and the chemicals (cytokines) that come with it; oxidative stress damaging brain tissue; activated microglia causing havoc; rogue proteins; failing mitochondria and so on. Chinese skullcap seems to address them all.
Consider these (PMID links)-
1. Brain Inj. 2009 Feb;23(2):146-53.
Scutellaria flavonoid supplementation reverses ageing-related cognitive
impairment and neuronal changes in aged rats. (19191093)
2. J Biol Chem. 2004 Jun 25;279(26):26846-57. Epub 2004 Apr 19.
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. (15096521)
3. CNS Neurol Disord Drug Targets. 2011 Mar;10(2):184-91.
Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in
4. FASEB J. 2003 Oct;17(13):1943-4. Epub 2003 Aug 1.
Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting
inflammatory activation of microglia. (12897065 )
5. J Biol Chem. 2004 Jun 25;279(26):26846-57. Epub 2004 Apr 19.
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and
disaggregates existing fibrils. (15096521 )
Originally Posted by sim00
Is about ten days I noticed a big improvement in my symptoms (+70 / 80%), tremor and bradykinesia, since taking two caps at a time of chinese skullcap in association with magnesium citrate and potassium, at empty stomach. After about 1 hour or so, my symptoms disappear almost completely, but the effect lasts a few hours (2 or 3), then I take another 2 caps and sometimes another again in the late afternoon. I can say that if I did not take these caps should increase the frequency of doses of Ldopa to feel better. I have yet to understand how this works exactly.