Originally Posted by Diego24
I know. I contacted the professor yesterday and asked him whether his results are promising for everyone or just a small subset of people with DJ-1 gene problem.
You say alpha-synuclein is not present in all PD patients ? A few days ago I thought I read somewhere that more than 80 % of PD patients have problems with alpha-synuclein.
Mere speculation. Unless something has profound has occurred, no standard measure exists for living patient, and the old standara of Lewy bodies upon autopsy mean nothing anymore. Did your source reveal how that 80% was arrived at? I may have missed something. I would love it if they had a valid and reliable measure in place.
Relying on Lewy Body formation as an alpha-syn measure is now what I would call bad science. Again there are people who have brains riddled with these clumps and never a tremor. We also have a genetic young onset PD with Park2 mutation that do not accumulate Lewy Bodies which are part of the aftermath of alpha-syn aggregation, toxicity, and neuronal death. Yet they look very much Parkinsonian; many of us with YOPD may have such a mutation but would never know it because those of us without a direct relative with PD are ignored by research. Never mind that only a tiny fraction of genetic PD cases (20 % over all) follow the classic Mendelian inheritance model.
This is why I get so annoyed by PD research. On the one hand they are saying that so few people have genetic mutations, so the vast majority of us are not worth testing. On the other hand, they will take a study like the one on DJ-1 and promote with abandon as a breakthrough for all of us. Just a wee bit of a problem, I find.
I have researched PD exhaustively for three years and decided that if they really had more heart in it and less ego we wouldn't be having this exchange right now. The CDC has no epidemiological data on neurodegenerative disease. Why is that? By keeping us ill and feeding us hope, we are the bread and butter of an industry. This is not a conspiracy theory, but the hard truth that in a Capitalist economy, disease is a commodity.
BTW, you are waiting on the researcher's reply?