Originally Posted by made it up
....your heading said it all...
On agonists and at my most boorish peaks I thought poetry along with my written opinion on just about anything was a great gift I'd only just unleashed and felt the need to share with others.
...was then rectified 10 yrs ago.
I looked up “boorish” and it really does describe me when I am sliding from On to Off.
Boorish: bad-mannered, barbaric, bearish, cantankerous, churlish, cloddish, clodhopping, clownish, clumsy, coarse, countrified, gross, gruff, ill-bred, ill-mannered, impolite, inurbane, loud, loutish, lowbred, oafish, ornery, out-of-line, out-of-order, provincial, rough, rude, rustic, swinish, tasteless, ugly, uncivilized, uncouth, uncultured, uneducated, ungracious, unpoised, unpolished, unrefined, and vulgar!!!
That about covers it. AND I also have Parkinson’s!
Pity my caregivers
But I do not believe that the panic outbursts of perception or emotion have been figured out and put safely away in the filing cabinet. We still don’t know what it is we don’t know. But we say, “Sometimes it feels like this”, or “That happened to me too.”
one end of the corridor - a pile of food,
other end - a pile of food twice as big
but surrounded by fence.
animals with low levels of dopamine (Off) choose the easier, smaller pile of food, where there is no fence
animals with high levels of dopamine (On) jump the fence, climb over the fence, chew through the fence, or dig under the fence, and get twice as much food, and a better rate of survival.
(and Parkies are yelling, “what side are you on?”)
dopamine spikes like amphetamine speed goofballs after stress, such as losing a street fight. Which has nothing to do with movement disorder or the pleasure of gambling
get in a street fight you produce more dopa. (Oh my. Barbarians at the gate_ Yes but we have a dress code)
Soldiers post-traumatic stress syndrome show rush of dopamine activity in brain when hearing recorded gunshots and other combat sounds. -
if dopamine is pleasure element, then why association with negative experiences?\ fight or flight survival decision - gets u excited because of danger, creativity is for survival
multi-system atrophy, ladies and gentleman; not just your substantia nigra going up in flames; it’s all your systems withering; systems pulling each other down like power failure that spreads by itself; one circuit overloading the nex t one….
Creativity is triggered because death comes knocking at your door, you put on your walking shoes and go down by the River Jordan;
and you search for meaning, at least to understand what is at the centre of Man’s Fate.
Pretty standard Darwinian stuff… assets and liabilities, strength and creativity to avoid extinction…/. Curing PD will be another victory for our DNA of problem solving and skills to attack or defend or flee, whether success or fail we do not know in advance, but we beat the sabre-tooth tigers, for whom we were cat-food 12,000 years ago. Our DNA remembers how we did that.
We killed smallpox and polio. By being creative, and deciding to fight.
Lack of dopa creates severe austerity and necessary rationing of resources to survive while trying to solve the puzzle, therefore soldier produces dopamine in response to gunfire, not for pleasure, not as movement disorder, but for fight or flight FROM SENSED DANGER; which may REQUIRE you to be creative to find a way through the deadly maze
Forced to make instant decision to go to small pile of food for immediate survival \
or take the risk of jumping the fence to get double supply of food.
Or find creative way to get both piles of food
Creative not for itself but activity to survive new dangers
You do the highest level you can handle, in your condition, at that place, at that time, with that level of dopa,mine u go to war with the dopa u got not the dopa u wish u had
\If you got lots of dopa, you go for the long shot; if dopa low, you play it safe
Not talkin Vegas here and pleasure rewards, talking battlefield and survival and fights and famine.
On or Off, ; not a pleasure centre. you can or you cannot jump the fence
Dopa signals how much you can handle at that moment in that place. If things aren’t looking so good, you conserve your energy, which they call “Parkinson’s lack of motivation.”
Lack of motivation? No, we are otherwise occupied. It takes us more “motivation” to get out of bed in the morning, than it takes most people to manage their careers. Lack of motivation? Here, put on these cement shoes and go jogging. And then let’s compare “motivation”.
Third choice is get sedated, so you won’t feel it happening one way or the other. But then you miss out on the whole experience of being a canary in the coalmine.
we are all just chemicals ? Nope. Man does not live by mirapex alone.
Creativity is called up when everything you thought you knew you no longer know.
Creativity is when your ship sinks and you have to build a life-raft with no tools
It’s not for the fun of it, but it is easier than sitting around waiting to die.