Little's latest (2013) paper:
"Objective: To assess the clinical value of online, self-reported PD symptom data recorded by users of the
health-focused Internet social research platform PatientsLikeMe (PLM), in which patients quantify their
symptoms on a regular basis on a subset of the Unified Parkinson‟s Disease Ratings Scale (UPDRS)."
6074 PD patients on PLM
100 included in this study, qualification to be included 15 UPDRS scores.
"Validation demonstrated the high-frequency self-reported data is consistent with a low-frequency clinical data
set in common use in clinical PD studies. The distributions of PLM to PD-DOC “off” scores are essentially the
Obviously it can be perfected, but as I see it, the technology is in place. The question now is:
Is there the political will to run simple clinical trials in this way?
 M.A. Little, P. Wicks, T.E. Vaughan, A. Pentland (2013)
Quantifying short term dynamics of Parkinson’s disease using self-reported symptom data from an Internet social network
Journal of Medical Internet Research, 2013;15(1):e20, doi:10.2196/jmir.2112