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Vitamin B6 Pyridoxine/P-5-P information:

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Unread 10-20-2008, 03:58 PM   #21
mrsD
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Lightbulb if it works for you

don't change. P5P is basically for people with failures in B6 metabolism. Since this has been a hidden issue, it is recommended for people with neuro problems (who may have metabolic failures and that is why they have neuro issues).

But if your product works for you, then you obviously don't need to change.

Nice to see you are back and safely too.
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Vowel Lady (10-22-2008)
Unread 02-27-2009, 08:35 AM   #22
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Thumbs up bumping with new information..

New studies show using high dose B6, B12, and Folate, reduces
macular degeneration. This study followed 5000 women for 7 years!

http://www.sciencenews.org/view/gene...protect_vision

Quote:
After 7.3 years of follow-up, those reports had turned up 82 cases of age-related macular degeneration among women taking placebos and only 55 cases in the women getting the vitamin supplements.

While an explanation for the apparent protection from macular degeneration remains unknown, it is known that folate, B-6 and B-12 can drive down blood concentrations of homocysteine, a compound suspected of damaging blood vessels. Researchers have tried to finger homocysteine in heart disease, but studies have failed to show a heart benefit from reducing homocysteine levels.
It is something to think about.
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Unread 02-27-2009, 08:54 AM   #23
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Sorry about the repetitive nature of this post, but it was noticeable for me how much improvement I felt in my energy levels when I started to take a B50 tablet and a B12 tablet (methyl type) regularly. Few of my vitamins have brought me this much noticeable difference. These are two tablets I make sure to never forget to take. I strongly believe in the power of the B vitamins and recommend them to everyone. Many of my friends are taking them now...including a friend in the medical field who took the time to do her own research and is now a big fan!
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Unread 02-27-2009, 10:17 AM   #24
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Default B6

A moderate to severe risk for someone with CMT if taking high doses of B6
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Unread 02-27-2009, 11:05 AM   #25
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Question

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Originally Posted by Kitt View Post
A moderate to severe risk for someone with CMT if taking high doses of B6
Depends on what is "high" to you. I doubt they took more than 50mg a day.

What dose do CMT patients find harmful?
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Unread 02-27-2009, 04:56 PM   #26
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It is not what is "high" to me. It is what the experts on CMT recommend. I should have said "mega dose" instead of "high". Sorry for that. I am specifically talking about CMT.

However, a mega dose of Vitamin B6 is 10 x the RDA allowance which is 20 mg. A neurologist who is an expert in CMT prefers no more than 10 mg daily. It can damage nerves in people who have CMT. There also can be other side effects. This allowance would include the foods you eat, drink, or supplements in the equation.

Obviously some people with CMT can get by with more depending where they are as far as CMT is concerned. None of us CMTers are the same. CMT varies greatly even within the same family. However, the recommendation is for anyone who has CMT whatever stage they are in or not. There are many types of CMT.

I only posted this so that a person with CMT who might be reading this would be aware. There is a medical alert list of many drugs that people with CMT should be aware of. We do not have the same peripheral neuropathy and other problems, that other people have.
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Unread 02-28-2009, 11:00 AM   #27
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Post list...

I found this list:

http://www.charcot-marie-tooth.org/med_alert.php

I think "mega" implies the 500mg that was commonly used in the past daily...for PMS and other maladies.

I wouldn't call 50mg a day "mega".

In fact the FDA has approved pyridoxine for pregnant women who have alot of vomiting issues. That dose is 75mg a day.
Metanx has 25mg of P5P (activated pyridoxine) in it. This would be easily equivalent to 50mg of pyridoxine (which is not activated). So it brings to mind the question... is the unactivated form that bothers CMT patients, or the P5P form?
From what I have gathered over the years, the P5P form is safer in people with special needs/problems. The "toxicity" of pyridoxine was only measured with the unactivated form, and is thought to pertain to IT only.

I also found it interesting that fluoroquinolones were classed as
minor. I think these drugs cause PN in many normal people!
They have become a real problem. I think they should be moved up the list.

Thanks for bringing it up, Kitt.
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Unread 02-28-2009, 02:58 PM   #28
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Default CMTers should go

by what the experts in CMT say. 50 mg is called a mega dose for people with CMT. It certainly is not a mega dose for the general population. I agree with that. I certainly will not jeopardize my PN with more than is called for.

What the FDA has approved for pregnant women who have a lot of vomiting is quite another matter. A pregnant woman with CMT should go by what the experts in CMT say. And, as mentioned before, there are many drugs, etc. that a person with CMT must be aware of. They should work closely with their neurologist/doctor who does know CMT.

As far as the general population, that is another matter. And, yes, the site you refer to is the Medical Alert list for people with CMT.

Apparently the experts have done their research concerning Floroquinolones for people with CMT and they are considered negliable or doubtful for people with CMT. They came to this conclusion thru their research and studies of people with CMT. The list does change now and then as to where the experts findings take them. Again, the list is for people with CMT.

For the most part CMT is an "inherited" peripheral neuropathy. There are 22+ types of CMT that they now can do DNA blood testing for. There are many kinds of CMT and there are about 50 types identified so far and there is no end in sight.

Thank you mrsD for your post.
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Last edited by Kitt; 02-28-2009 at 03:16 PM.
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Unread 10-16-2009, 10:47 AM   #29
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mrs d......have a patient in ltc, that has elevated B6....on no sup...hx of etoh abuse....female......would a zinc sup, and p5p be the way to go? her doc appears to be open to some nutritional suggestions....patient def has mood issues.....and has been dx with dementia......

Last edited by pabb; 10-16-2009 at 01:05 PM.
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Unread 10-16-2009, 10:57 AM   #30
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Lightbulb

If B6 is building up in the blood, this indicates to me that your patient is not converting it to the active form.

There are studies that autistic patients have elevated B6 this way too, with no history of vitamin supplement intake.

B2 Riboflavin is the cofactor in the enzyme pyridoxal kinase. If B2 is lacking, pyridoxal cannot be made from pyridoxine.

This enzyme is also affected by some drugs. Theophylline is one.
I have also read that "amine" drugs also affect this enzyme.
Here is one study:
http://www.sciencedirect.com/science...5eda525e449a6e

Quote:
Depending on the results, the inhibiting drugs were divided into three groups. The first group included theophylline and progabide and inhibited PLK using either PL or pyridoxamine (PM) as substrate and thereby were true inhibitors. Moreover, they did not form covalent complexes with PL or PLP. The second group, which included cycloserine, dopamine, isoniazid, and thiamphenicol glycinate, inhibited PLK using PL, but not PM, as substrate. They were able to react with PL or PLP to form covalent complexes, and kinetic studies suggested that the observed PLK inhibition was due to these formed complexes. A third group, which consisted of levodopa, D-penicillamine, and muzolimine, inhibited PLK using PL, but not PM, as substrate.
I think the jury is still out on other drugs at this time.

This paper discusses testing the enzyme, and lists nicotine and
theobromine as inhibitors, as well as a cousin of theophylline.
http://74.125.95.132/search?q=cache:...&ct=clnk&gl=us
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