Off-label medication relief of PD symptoms

therese · 10-07-2008, 10:46 AM

Good morning, everyone...I have not posted in a very long time, but I read the messages, here, regularly.

I would like to ask if anyone has ever experienced relief of a PD symptom while taking an antibiotic? My pwp has been taking an antibiotic for an infection for 5 days, now, and her tremor (her predominant symptom) SEEMS to have disappeared! It almost seems beyond coincidental. I wonder if this could be considered to be an "off label" use (I believe that's the term used when a medication geared to treat a specific ailment results in relief of another symptom for which it has not been specifically prescribed. It seems to me that there has been some speculation about viruses having some connection to PD (not really certain about this). I would appreciate any input that you may have about this.

Thank you...it's good to be back. I always know where I have to go when I have a question related to PD.

Therese

reverett123 · 10-07-2008, 06:18 PM

There have been numerous "anecdotes" about this. Unfortunately, in the medico world, "anecdote" means "silly patient story" so they are dismissed.

A couple of years ago, Ron Hutton ran across a letter in an "Ask the Doc" column from a PWP who had gone to the emergency room with an abscessed tooth and had been given Penicillin VK. His symptoms totally disappeared within a couple of days and returned a couple of days after he ran out. The doc dismissed it out of hand.

The tetracyclines have long produced such stories, as well. In fact, a member of that family called minocycline has a good bit of research published on it.

There are a couple of questions to be answered. What is going on? The first thought is that some bacterium is causing the symptoms, but, if so, why don't more antibiotics produce results like this? Why hasn't someone been cured accidentally?

I suspect that the answer is a little more interesting. As I have posted from time to time, I believe the theory that we are hypersensitive to the bacterial endotoxin lipopolysaccharide (LPS) due to our having encountered it in the womb. Now as adults, the barest whiff of LPS wafting through our system makes our brain's microglial cells go berserk and start pumping out cytokines which, uncontrolled, do great damage in the long term and screw up our neurofunction in the short term.

If it isn't beating back bacteria, then what is the antibiotic doing that makes a difference in PD? Glad you asked!!

These antibiotics have another property of note- they bind LPS and render it harmless! That, in turn, allows the microglia to stand down. The antibiotics are acting as anti-inflammatories.

Some other things that support this- Remember how ibuprofen offers protection bt aspirin does not? Ibuprofen binds LPS but not aspirin.

And then there is cholesterol. Despite what Big Pharma wants us to believe, low cholesterol increases one's chance of getting PD. One reason is probably the fact that cholesterol is a component of the neuronal wall. But there is another- the body handles LPS by binding it to cholesterol for transport to the liver.

And, as Paul Harvey says if they pay him enough, "That's the rest of the story..."

therese · 10-08-2008, 02:57 PM

...for your response to my question about off-label relief of PD symptoms...and yes...I AM glad that I asked!!!!!!
You have such a great ability to explain/describe things in technical terms, but, believe it or not, I understood what you said!!!! LOL Interestingly, I think, was the fact that you mentioned the Penicillin VK. Doreen is taking Amoxicillin (same family, right, Ron?)...both within a classification of "older medications" which, quite frankly, I feel work better and are safer than many of the newer medications that are "rushed" onto the market these days. Of course, Doreen's response to all this was: "How long, though, can one continue to take an antibiotic?" I told her that something like this might fit into the category of a type therapy (cannot recall the exact name right now)...that is used wherein a person takes a specific antibiotic for a certain length of time; then, the antibiotic is changed and taken for a length of time, etc. You probably know the techinical term for this, Ron!!! It just escapes me at this moment. At any rate, we'll see where this might go...and thank you again, Ron, for your response. I appreciate it very much.

Therese

reverett123 · 10-08-2008, 05:40 PM

You know what I like about this place? It's just like home!

Ronhutton · 10-09-2008, 04:58 AM

Hi Theresa (and Rick)
I can't bask in the glory any longer!! LOL
Theresa, it was Rick who replied to you not me, but then what you probably don't know is he is wearing my hat in his photo, hence the confusion.
Rick and his wife Wanda, came over to Merry England and stayed for an enjoyable 2 weeks with us. The photo he uses is part of a photo of him and I sitting in our garden. If I could find the photo, and then find how to include it in my post, I would let you see it.
Best wishes
Ron

mrsD · 10-09-2008, 07:31 AM

When some people as children are infected with Strep, they make antibodies to the bacteria which when the infection is over, then attack the brain (it is thought there is a genetic sequence on the antibody that resembles something in a brain structure) which then malfunctions and gives TOURETTE'S. (this is similar in mechanism to thoughts on how Type I diabetes occurs...that autoimmune complexes to Bovine insulin in milk products induces reactions to human islet cells--Type I often occurs after a triggering infection).

What is Tourette's? A MOVEMENT disorder.
And typically the treatment involves long term use of a pencillin derivative to keep the Strep at bay (we all have bacteria in us, which are in low level amounts, that our immune system is successfully dealing with). So these kids take Penicillin VK or Amoxicillin or if allergic cephalexin.

So if an antibiotic works, it may be MORE than affecting inflammatory cytokines, it might be a form of ADULT Tourette's? It is something to think about.

reverett123 · 10-09-2008, 08:20 AM

You must admit, the resemblence is uncanny!

Quote:

Originally Posted by Ronhutton

Hi Theresa (and Rick)
I can't bask in the glory any longer!! LOL
Theresa, it was Rick who replied to you not me, but then what you probably don't know is he is wearing my hat in his photo, hence the confusion.
Rick and his wife Wanda, came over to Merry England and stayed for an enjoyable 2 weeks with us. The photo he uses is part of a photo of him and I sitting in our garden. If I could find the photo, and then find how to include it in my post, I would let you see it.
Best wishes
Ron