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article on Aniracetam and brain injury rehabilitation

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Unread 09-05-2009, 11:42 AM   #11
mhr4
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That's great to hear. FYI, aniracetam is fat soluble, so make sure you take it with food and preferably with some sort of good fat. Also, if aniracetam doesn't work for you, then you should try oxiracetam. From what I have read, people either respond to one or the other. However, the research also stated that almost every head injured patient responds to it because we are all deficient in the area(s) the medication works on. It also has a half life of a couple of hours, so make sure to take it twice a day.

I begin my aniracetam/alpha gpc trial on Monday. It will be interesting to compare notes. Good Luck!




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Originally Posted by Mikeyy View Post
im gonna give this a shot! I ordered ALPHA GPC and aniracetam about 5 mins ago, should be in my hands in im assuming 10 business days.. ill be sure to post results
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Unread 09-05-2009, 11:59 AM   #12
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what do they say as far as taking it for a long term? Is it something you can take until your body is able to sustain that level or is it something you'd almost expect to need to take for a long time
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Unread 09-05-2009, 12:11 PM   #13
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I haven't actually found any articles on long term use. Most of the studies I read had their participants on the 'racetams for 6 months, but there were not follow up studies done. One guy, who posts on another forum, has been using it for 5 years, and he says that he hasn't built up a tolerance to it. I would imagine that you'll have to be on it indefinitely to get he maximum benefits from it. However, I did find a wholesale supplier out of China who sells 1 kg of it for $150 (all of this stuff is made in China right now). I haven't done the math, but my guess is that this would last at least 6 months. So, if you find you like it, let me know and I'll pm you their information. Also, while I'm on the topic of long term use, some people recommend to cycle this stuff. Not sure what that cycle entails, but just make sure you cycle off of it once in a while.

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what do they say as far as taking it for a long term? Is it something you can take until your body is able to sustain that level or is it something you'd almost expect to need to take for a long time
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Unread 09-05-2009, 12:18 PM   #14
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ya im not much of a pill popper, I mean if it helps great im all for it as long as its clean, but the last thing I want is to become reliant on it.. I get annoyed taking pills.. even the travacor.balanced thing gets irritating lol, maybe im just lazy!
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Unread 09-05-2009, 03:05 PM   #15
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well the nice thing about it is that is has shown to demonstrate neuroprotection against dementia. So, taking it long term may not be such a bad thing.


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Originally Posted by Mikeyy View Post
ya im not much of a pill popper, I mean if it helps great im all for it as long as its clean, but the last thing I want is to become reliant on it.. I get annoyed taking pills.. even the travacor.balanced thing gets irritating lol, maybe im just lazy!
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Unread 09-07-2009, 12:31 PM   #16
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Quote:
Originally Posted by Mikeyy View Post
im gonna give this a shot! I ordered ALPHA GPC and aniracetam about 5 mins ago, should be in my hands in im assuming 10 business days.. ill be sure to post results

mike aniracetam is an effective treatment for cognitive impairment induced by TBI, even when treatment is delayed for a period of days following injury. like the new stroke drugs these drugs only limit the after burn effect of brain injury, so please take care with self medicating , supplements, are fine but I draw the line at advising anything stronger

TC
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Unread 09-07-2009, 12:32 PM   #17
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*edit* information about the beta amyloid plaque formation. *edit* You may be able to find this information by googling aniracetam and alzheimer's. I found it on an Alzheimer's forum.

The FDA is working hard to stop the flow of Aniracetam into this country. The importers are claiming it is a nutritional supplement but it is a in reality a synthesized drug.

It is definitely contra-indicated for anybody with a family history of Alzheimer's. It can cause beta-amyloid plaque to build up faster for those with the Alzheimer's plaque problem.

I have looked into it extensively and was considering buying some, but then learned about the plaque problem.

As for the Alpha GPC, I have found that Choline CDC is considered a better choline supplement. The Alpha GPC has a storied history. The Choline CDC does not and has been studied for much longer.
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59 years old, retired due to disability, married 34 years, father of three, grandfather of four, Suffered a serious concussion at 10 years old (1965) stopped most driving after concussion at 46 years old (2001), Post Concussion Syndrome/Multiple Concussion/Impact Syndrome with PTSD, immediate/short term visual and auditory memory problems, slowed processing speed, visual/auditory processing difficulties, insomnia, absence seizures, OCD, 14 concussions since first concussion at 8 years old, Taking paroxetine for 14 years and gabapentin for 12 years. Added L-Tryptophan and stopped paroxetine after 3 months of tapering. I currently take 500 mgs of L-Tryptophan AM, 500 mgs noon, and 500 mgs PM.


As of Nov 15th, Due to high stress issues resulting in PTSD, docs put me on 3 meds. Clonazepam but only for 30 days ) .125 mgs twice daily (Doc presc. .25 mgs 2x daily but half a tablet is good) , citalopram (Celexa), an SSRI , and olanzapine (Zyprexa), an atypical anti-psychotic that usually causes weight gain before bed. I lost over 30 pounds since mid July. It just stopped the weight loss. Took me off the gabapentin. I am feeling better than I have in years.

This great feeling only lasted a month. Back to the same old PCS doldrums.

May 2014, I am off the olanzapine due to a 6 fold price increase. Back on 600 mgs of gabapentin before bed.

I am also taking L-Theanine to help with GABA regulation


"Be Still and Know That I am God" Psalm 46:10

Last edited by Jo*mar; 09-07-2009 at 01:35 PM. Reason: per guidelines
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Unread 09-07-2009, 01:54 PM   #18
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Unread 09-08-2009, 03:24 PM   #19
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Mark,

Can you provide evidence of this? I ran a google search and found nothing. I actually found a myriad of studies that used aniracetam to prevent the worsening of symptoms from alzheimers. Why would scientists use a drug to combat alzheimers if it has been shown to induce the very thing that causes alzheimers? No offense, but it doesn't seem like sound logic to me.

Also, can you please provide evidence that CDC Choline is superior to Alpha GPC? I have always read on forums that Alpha GPC is far superior to CDC Choline. Alpha GPC is even more expensive to buy than CDC Choline. Simple economics would suggest that the superior product would be more expensive. But please, if you have solid evidence, please provide it so I can start buying the cheaper one.

I also found nothing on the FDA trying to ban the importation of aniracetam. Please provide evidence to this as well. I did find one person who stated primaracetam is getting harder to find and they speculated that this could be due to the FDA, but I would hardly consider this person a valid source.



Quote:
Originally Posted by Mark in Idaho View Post
*edit* information about the beta amyloid plaque formation. *edit* You may be able to find this information by googling aniracetam and alzheimer's. I found it on an Alzheimer's forum.

The FDA is working hard to stop the flow of Aniracetam into this country. The importers are claiming it is a nutritional supplement but it is a in reality a synthesized drug.

It is definitely contra-indicated for anybody with a family history of Alzheimer's. It can cause beta-amyloid plaque to build up faster for those with the Alzheimer's plaque problem.

I have looked into it extensively and was considering buying some, but then learned about the plaque problem.

As for the Alpha GPC, I have found that Choline CDC is considered a better choline supplement. The Alpha GPC has a storied history. The Choline CDC does not and has been studied for much longer.

Last edited by mhr4; 09-08-2009 at 04:13 PM.
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Unread 09-09-2009, 01:11 AM   #20
Mark in Idaho
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I have tried to get the actual text of the reports I found referenced. Unfortunately, I do not have subscriptions to the text that allow copy and paste. The Abstracts do not say much worth repeating.

One reference says that a study was conducted in Japan in 2000-2001 and due to negative results, the study was not completed. Another comment says that due to an article with a negative result the drug (trade name Draganon) was delisted. It may be referring to the Japan study.

Keep in mind that there are many different kinds of studies. In one abstract of a review of the published literature, it commented that there were myriads of both pro and con reports about Aniracetam and Piracetam.

It did not include a review of most of the reports because the methodology was not scientific due to open label, lack of adequate pre and post trial testing (neuropsych) or other statistical problems. A common problem was combining too many different types of dementia. In one report reviewed, the cohort was 150 patients. Upon thorough review of the patient histories, only 19 were properly qualified for the study as it was designed.

It was the Alpha GPC that was problematic to AD plaque formation, not the Aniracetam. The same was true of the CDC Choline (Citocholine). The AD brain already has an excess of acetylcholine.

As brain injury has been found to relate to a 4 to 10 fold increase in the prevalence of Alzheimer's Disease, it is easy to combine the two and see the long term risk.

There is a common problem with brain injury/dementia studies. It is all but impossible to get enough volunteers to participate in a long term double blind study because many of the patients are not willing to delay what ever other treatments may be available. A properly designed study needs to isolate the subjects from other treatments and therapies.

The studies of subjects with Alzheimer's were usually cut short unless positive results were documented early in the study.

I can not get the required written authorizations for the other information from another forum so that I can post it.

Either way, After my preliminary research, I discussed it with my wife and I was about to order some Aniracetam and CDC Choline to try but now will not take the risk.

I may have horrible memory problems and slowed thinking but my intelligence is still intact. I can not imagine losing any more mental abilities. I know what it is like to lose mental skills step by step over the last 40 years. This last step of lost skills was devastating. I cannot afford another step down in brain function.

By the way, in reviewing some past posts, it appears I never answered an important question. Why did the neurologist and neurofeedback therapist suggest neurofeedback was not recommended for my case? He could tell from the level of damage shown in my 22 lead QEEG that I have serious damage beyond the level that would be recoverable due to neuroplasticity.

He believed that my multiple concussions (13) had just finally overwhelmed my brain's ability to rewire. He based some of his prognosis on my reports of my prior successful brain retraining. He was actually shocked at my high level of functioning considering the damage shown in my QEEG waveforms. He did not know how bad my function was a year earlier. I had learned many work-arounds and accommodations to hide my dysfunctions.

This neuropsychiatrist had a full time clinic that kept busy and profitable doing neurofeedback. He used a QEEG targeted system, not a take home shotgun approach. At the time, I had the money to spend. His QEEG tech had recovered from a brain tumor and two-lobe-ectomy and used brain retraining to go on to earn a master's degree.

I had had very good recoveries from most of my concussions until a concussion in 1996. I worked hard at brain retraining and got intellectual functions and memory back to a high level but never regained tolerance for visual or auditory stimuli.

I was assaulted from behind with a blow the the head in 1999 and has even more struggle to recover. A new injury in Jan 2001 was the end to my ability to recover.

Upon starting serious research into brain injuries, I was able to define the functions I had been losing step by step after each concussion. It was like at each concussion, I took three steps back and recovered with two steps forward. Finally, it was three steps back and one step forward then no steps forward.

When I started devoting my energies to learning work-arounds and accommodations, my ability to function at a high level returned, not 100% nor 24/7 but enough that I could rest up for an event where I needed maximum function.
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Mark in Idaho

59 years old, retired due to disability, married 34 years, father of three, grandfather of four, Suffered a serious concussion at 10 years old (1965) stopped most driving after concussion at 46 years old (2001), Post Concussion Syndrome/Multiple Concussion/Impact Syndrome with PTSD, immediate/short term visual and auditory memory problems, slowed processing speed, visual/auditory processing difficulties, insomnia, absence seizures, OCD, 14 concussions since first concussion at 8 years old, Taking paroxetine for 14 years and gabapentin for 12 years. Added L-Tryptophan and stopped paroxetine after 3 months of tapering. I currently take 500 mgs of L-Tryptophan AM, 500 mgs noon, and 500 mgs PM.


As of Nov 15th, Due to high stress issues resulting in PTSD, docs put me on 3 meds. Clonazepam but only for 30 days ) .125 mgs twice daily (Doc presc. .25 mgs 2x daily but half a tablet is good) , citalopram (Celexa), an SSRI , and olanzapine (Zyprexa), an atypical anti-psychotic that usually causes weight gain before bed. I lost over 30 pounds since mid July. It just stopped the weight loss. Took me off the gabapentin. I am feeling better than I have in years.

This great feeling only lasted a month. Back to the same old PCS doldrums.

May 2014, I am off the olanzapine due to a 6 fold price increase. Back on 600 mgs of gabapentin before bed.

I am also taking L-Theanine to help with GABA regulation


"Be Still and Know That I am God" Psalm 46:10
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