Since this thread started, we have learned that lipoic acid is best absorbed in another form, called stabilized. This is a form that is highly water soluble and therefore, less is needed per dose,
and it is far more effective.
This formula does not give this ingredient as "stabilized".
So expecting a huge response from that one is not likely.
Some people need more of one thing than another. Some people may react negatively to one thing in a mixture like that and then have to stop the whole thing, thereby losing any benefits from the other ingredients.
In pharmacy we call this "shot gun" therapy. It may work, or it may partially work, or it may have to be stopped for some reason.
For example, I react to high dose lipoic acid... so I have to keep it at 100mg a day. At that dose using stabilized, I do get response, and had some good HbA1C results this last testing time. So that is just one example.
It can be difficult figuring out what is going on with PN however, and so we then see all sorts of "remedies" posted on our forum as a result.
I personally think people with Chemo damage, need different things than those with nutritional deficiencies, or autoimmune damage.
I tend to like to buy my supplements separately, and I choose quality manufacturing places with a good history of care and accuracy. When a new thing comes out we often don't know much about who makes it, for example. So there are many reasons to be careful. But being careful does not mean throwing away potential.