Go Back   NeuroTalk Support Groups > Health Conditions M - Z > Peripheral Neuropathy

Paraprotein Related Neuropathy

Reply
Thread Tools Display Modes
Unread 12-10-2010, 01:43 AM   #1
rose_thorn98
Member
 
Join Date: Oct 2010
Posts: 190
My Mood:
Default Paraprotein Related Neuropathy

The only test form me so far to show anything is elevated IgA. At first they thought this might indicate Celiac, but intestinal biopsy was negative.

Now, my neuro is having me do a urine test, to test for Paraprotein Related Neuropathy. It is a test that will show if there is Monoclonal proteins, usually IgM, IgG, or IgA with either kappa or lambda light chains.

I'm anxious to see if this will point out anything for me. I've noticed that some people here have had some paraneoplastic testing done, but I didn't notice if you all had had this kind of test done. It is a immunoelectrophoresis test. Sound familiar to anyone?

Here is a link to a paper that talks about Paraportein Related Neuropathy:

http://www.dcmsonline.org/jax-medici...uropathies.htm
rose_thorn98 is offline   Reply With Quote
Unread 12-10-2010, 07:17 AM   #2
glenntaj
Magnate
Community Welcome Team
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,465
My Mood:
Default Yes--

--an immunofixatin electrophoresis for blood and urine to enumerate immunoglobulin levels and to look for paraproteins/monoclonals, which are rogue antibodies that can cause neuropathy by interacting with the nerve gangliosides, SHOULD be a standrad test for those presenting with neuropathic symptoms.

I say SHOULD because far too many doctors don't think to order it, or order only a serum protein anlysis, which is not specific enough and. while it may reveal large levations in protein overall, cannot analyze small elevations or type.

Take a look at:

http://neuromuscular.wustl.edu/antibody/mprotein.htm
glenntaj is offline   Reply With Quote
Unread 12-10-2010, 07:29 AM   #3
mrsD
Super Moderator
 
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 28,327
Lightbulb

I found this site very interesting:

http://www.lymphomation.org/tests-immunoglobulins.htm
__________________
aka mrsdoubtfyre
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
Mama gray squirrel hanging upside down on our flat feeder 2014. She is very beautiful IMO and has a lovely tail. There were a few peanuts in this feeder that morning.
************************************
Please use the search function to find more information here in our forums. Your keyword must be at least 4 letters long. This is the handy link:


************************************
Here is a link to our guidelines that explains how to post links and information properly here due to copyright laws:

mrsD is offline   Reply With Quote
Unread 12-10-2010, 09:39 PM   #4
athena
Junior Member
 
Join Date: Aug 2010
Posts: 22
Default

Quote:
Originally Posted by rose_thorn98 View Post
The only test form me so far to show anything is elevated IgA. At first they thought this might indicate Celiac, but intestinal biopsy was negative.
]
I, too, had an elevated IgA but negative gliadin antibodies which was very exciting until the next test showed a drop to a high normal level.

This is my favorite article addressing neuropathy and monoclonal gammopathy (elevation in one of the immunoglobulins):

http://myeloma.org/ArticlePage.action?articleId=750

Best of luck. I hope you're on to something!

Athena
athena is offline   Reply With Quote
"Thanks for this!" says:
mrsD (12-11-2010)
Unread 12-11-2010, 12:05 AM   #5
invisable
Member
 
Join Date: Jul 2010
Posts: 298
My Mood:
Default Very interesting.....

Quote:
Originally Posted by rose_thorn98 View Post
The only test form me so far to show anything is elevated IgA. At first they thought this might indicate Celiac, but intestinal biopsy was negative.

Now, my neuro is having me do a urine test, to test for Paraprotein Related Neuropathy. It is a test that will show if there is Monoclonal proteins, usually IgM, IgG, or IgA with either kappa or lambda light chains.

I'm anxious to see if this will point out anything for me. I've noticed that some people here have had some paraneoplastic testing done, but I didn't notice if you all had had this kind of test done. It is a immunoelectrophoresis test. Sound familiar to anyone?

Here is a link to a paper that talks about Paraportein Related Neuropathy:

http://www.dcmsonline.org/jax-medici...uropathies.htm
Thanks for link, yes I did have the urine & serum test for this. Nadda for me (as usual.) Isn't it odd to be disappointed when something isn't wrong and comes out negative?! I know you all understand though.
invisable is offline   Reply With Quote
Unread 05-05-2011, 08:08 PM   #6
Tulips
Member
 
Join Date: Oct 2010
Posts: 148
My Mood:
Default Glen

I had spep with random urine. Should they do 24 hour urine too. Plus spep was negative but when the immunologist did a special test called Hiss panel, it showed elevated Ige, igg, and iga. Plus subclass ig2.

Now the light chains are not done yet. Does these elevation mean autoimmune disease is probably going on?

Thanks
Tulips is offline   Reply With Quote
Unread 05-06-2011, 06:45 AM   #7
glenntaj
Magnate
Community Welcome Team
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,465
My Mood:
Default In the sense of autoimmune disease--

--linked to rogue antibodies being produced in the bone marrow and being introduced into the circulatory system, not necessarily.

The type of antibodies associated with blood diseases can be class IgM, IgA, or IgG, but they are generally monocolonal in nature, which is generally only revealed with the more specific immunofixation electrophoresis (IEP) test, generally down along with a quantitative enumeration of antibodies. One can have elevated polyclonal (e.g., more "normal" antibodies that are produced to specific antigens) for a lot of different reasons, including rather standard infections--the monoclonals generally show up only when there is a disease process going on in the bone marrow in which too many of these are produced without a corresponding bodily reason. (They tend to proliferate in blood cancers, for instance.)

They should do a 24-hour urine tests to look for Bence-Jones proteins, and the IEP with immunoglobulin enumeration:

http://neuromuscular.wustl.edu/antibody/mprotein.htm

I've posted that link before, but wanted to also post this one about paraproteins not associated with blood cancers, but with more solid tumors--those are associated with antibodies not produced in the bone marrow, but by the tumors themselves:

http://neuromuscular.wustl.edu/nother/paraneo.htm
glenntaj is offline   Reply With Quote
"Thanks for this!" says:
Tulips (05-07-2011)
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
peripheral neuropathy (diabetes related) Mary94 Peripheral Neuropathy 4 07-02-2010 08:47 PM
Small Fiber Neuropathy (or Length-Dependent Neuropathy) plgerrard PN Tips, Resources, Supplements & Other Treatments 1 05-09-2010 06:56 AM
alcohol related neuropathy cheryllawson Peripheral Neuropathy 11 04-27-2008 03:59 PM
alcohol related neuropathy cheryllawson Peripheral Neuropathy 0 04-24-2008 09:42 AM
Not sure if its related, but it might help Dmom3005 Traumatic Brain Injury and Post Concussion Syndrome 0 07-10-2007 08:58 PM


All times are GMT -5. The time now is 02:00 AM.
Brought to you by the fine folks who publish mental health and psychology information at Psych Central Mental Health Forums

The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider. Always consult your doctor before trying anything you read here.


Powered by vBulletin • Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.


All posts copyright their original authors Community Guidelines Terms of Use Privacy Policy
NeuroTalk Archives