There is one study done on rats, only using ALA (the racemic mixture of active and inactive parts) that some thyroid suppression was demonstrated.
No studies have been done on the lower dose r-lipoic at all or any on humans that I have seen yet.
You stated that you stopped taking your thyroid for a while. This would be cold turkey, depriving your body of the hormone when it needed it. And it would take a while to fix that biological effect in the tissues.
This is the study done in 1991 on animals, and has not be replicated or further explored.
It does show up tho on sites that publish information on supplements. When shown this way out of context, it is not very useful IMO. But it is used for liability reasons.
You can discontinue if you want to see if there is a change. But while you do so, you are still taking the hormone which is changing things daily...so basic effects would not be clear.
It is up to you to decide with your doctor. Just remember, lipoic acid exists in the body, naturally anyway.
Here is a link with more information:
At the bottom is a medical explanation of the isomers, etc.
A search on this topic on PubMed did not reveal any new information about this potential. Only 9 papers, and only the one I quoted is specific.
Another factor in thyroid hormone use is the carrier proteins. Protein binding is needed to carry the hormone around the body. If the proteins are not present, then the hormone expression decreases. This happens in males, who develop low carrier proteins, due to various reasons including malnutrition. Protein binding carries testosterone for them, and low testosterone results.
This explains protein binding in general:
Here is a detail explaining the thyroglobulin binding involving thyroid:
More details here:
you can join for free to read medscape... easy and quick to do.
They have copyright, so I cannot quote them.
It does state that acquired low thyroglobulin occurs in various disease states, kidney damage/failure, liver failure, Cushing's syndrome, and various protein malnutritions. Albumin is involved so if you are low in albumin, you may be low in this binding protein level also.
I do know that certain drugs can displace thyroid hormone off these proteins. That can get pretty complicated, and a specialist in thyroid function would be the resource to consult for this.
Originally Posted by catloucle
I know that the combination of CoQ10, Acetyl L-Carnitine and R Lipoic Acid are necessary to feed the mitochondria to encourage nerve healing especially since I have a history of statin use (I stopped 6 months ago).
I am also hypothyroid and have been on levoxyl 150 mcg for over 10 years. Now I am having problems and just had blood work done and have a tsh of 7.48. I am having swelling of ankles and feet, quick weight gain, severe fatigue. My internist upped my levoxyl to 175 mcg and has already ruled out coronary, liver and kidney problems.
Doing research, I have learned that Lipoic acid use lowers level of thyroid hormones and inhibits T4 to T3 conversion of levoxyl. I have been using the "mito combo" for about 6 months.
Further blood work is being done for the thyroid. My question is if stopping the lipoic acid and just continuing the coQ10 and acetyl l-carnitine will be enough to feed the mitochondria? Is there another supplement I can use that is more thyroid friendly than the lipoic acid?
Thank you, Cat