Originally Posted by docwithms
I'm not sure if this will post right as I've never done this before but while searching for high dose prednisone in MS I came across your entry. I am a physician and have taken 1000 mg prednisone a day for 3 days ever 3 months for the past year and just found out that my MS lesions have regressed or disappeared?!?!? My neurologist always had me take my prednisone starting very early in the morning so I never was up all night until maybe the last day and then I was just up late, but very happy and productive! Talk to your doctor about the timing and also about giving you something to help you sleep during the times you're on Prednisone. Do you know of any literature supporting this high dose therapy? I stopped a few months ago because I was worried about steroid related complications such as avascular hip necrosis and also because I just had an early melanoma removed. Now with my new MRI findings, I'm rethinking. My understanding was that this high dose Pred was experimental and I was using it off label.
I was part of a trial for high dose prednisone. I did have to take an equivalent of 1 gram a day for 5 days orally every 4 months. Yup, it's a lot of pills. As advised by the clinical coordinator, I took 1/2 of them at breakfast time and the other 1/2 at lunch. I didn't have too much stomach issues with them nor did I have any major side effects other than puffing up like a puffer fish. lol.
I tolerated the oral 'roids far better than the IV. The IVSM, even at a slower drip rate of 1 gram over 4 hours, still make me sick.
Red - I hope you are doing much better now. You are almost 1/2 way through your 1st year and, as many will agree, the 1st year can be the toughest.