I too think natural dopamine function can return, if only because I WANT to believe that, ha ha, but also because of the studies they are doing with exercise helping PD. The Cleveland Clinic is doing the study on tandem cycling, there are others out there, and there are MANY neuros AND PWP who see improvement when the patient undertakes, and commits to, an exercise program. What else explains the improvement, and sometimes reduction of meds, if not better natural production of dopamine? I guess one could argue that the brain is not actually making more dopamine, it's just more efficiently using what's in there, but to me, I would not quibble over such a difference. If one is able to feel better, without taking more meds, and oftentimes actually reduce the meds once exercise program has begun, something good is going on inside that brain at an organic, natural level.
Why don't they do a PET/SPECT or whatever it is scan WHILE someone with PD is actually exercising like crazy on the stationary bike to see what is going on? There are so many tecniques they now have to be able to see what is going on inside our brain, seems like those could be used in this way. Hello, MIT?